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Endocrine Abstracts

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ea0098b2 | Basic Science | NANETS2023

TMEM127 exerts a tumor suppressive role in pheochromocytoma by mediating RET ubiquitin-dependent degradation

Gonzalez-Cantu Hector , Guo Qianjin , Cheng Zi-Ming , Rotondi Matthew , Huelgas-Morales Gabriela , Lefkowitz Jonathan , Ethiraj Purushoth , Qiu Zhijun , Song Wan , Landry Bethany N. , Lopez Hector , Estrada-Zuniga Cynthia M. , Goyal Shivi , Aasif Khan Mohammad , Walker Timothy J. , Wang Exing , Li Fagian , Ding Yanli , Aguiar Ricardo C. T. , Mulligan Lois M. , Dahia Patricia L. M.

Background: TMEM127 encodes for a ubiquitously expressed transmembrane protein with limited knowledge into its role. TMEM127 germline loss-of-function is a driver of pheochromocytoma and paraganglioma (PPGLs), tumors derived from the adrenal medulla and extra-adrenal paraganglia, respectively. Molecularly, TMEM127 mutant PPGLs belong to the kinase cluster, characterized by kinase signaling transcriptional programs. Receptor tyrosine kinase RET, a driver of PPGLs via germline o...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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