Searchable abstracts of presentations at key conferences in endocrinology

ea0028p346 | Thyroid | SFEBES2012

Investigation of thyroglobulin antibody assay discordance

Pickett Alan , Jones Meinir , Evans Carol

Measurement of anti-thyroglobulin (TgAb) predicts interference in thyroblobulin (Tg) assays and is a tumour marker for differentiated thyroid cancer (dtc). However, there is poor concordance between methods. This is attributed to the nature of TgAb, the method and cut-off used. We have assessed concordance between three TgAb assays and investigated the cause of discordant results. TgAb was measured in sera from 606 different patients being treated for dtc using the Abbott Arch...

ea0090ep710 | Pituitary and Neuroendocrinology | ECE2023

Serum prolactin levels and correlation to clinical diagnosis: a study of 259 patients with hyperprolactinaemia

Yin Win Lei , Evans Carol , Tennant Sarah , Lansdown Andrew

Introduction: Hyperprolactinaemia is a common finding in endocrine practice and can be due to a number of causes. The degree of elevation of prolactin levels may sometimes be helpful in distinguishing between underlying aetiology.Aim: To determine if hyperprolactinaemia is correlated with clinical diagnosis in a cohort of patients in the endocrine service at a tertiary centre.Methods: A biochemistry database held at University Hosp...

ea0063p487 | Calcium and Bone 2 | ECE2019

Hypercalcaemia: hypervitaminosis D or not ?

Zouras Stamatios , Evans Carol , Nalla Preethi , Lansdown Andrew , Rees Aled

Abstract: The most commonly used techniques to measure vitamin D are automated immunoassays, which are known to be affected by interferences, especially from immunoglobulins present in the patientÂ’s serum. We present a case of a patient with IgA myeloma in whom interference with the vitamin D assay was identified. An 76-year-old male, known to have: ischemic heart disease, atrial fibrillation, COPD, type 2 Diabetes Mellitus and hypertension was referred to the Endocrinolo...

ea0013p208 | AMEND Young Investigator's Award | SFEBES2007

An audit of chromogranin requests at a tertiary neuroendocrine referral centre

Kalhan Atul , Evans Carol , Scanlon Maurice , Rees Aled

Background: Chromogranin A and B (CgA, CgB) are widely used as markers of neuroendocrine tumour (NET) disease. However, the sensitivity of the test is variable and the value of CgB measurement is unclear. We thus sought to review 3 years of CgA and CgB requests made in our hospital.Methods: CgA and CgB were measured at the Hammersmith Hospital. Case notes were reviewed in each of these patients.Results: There were 520 tests perform...

ea0050p007 | Adrenal and Steroids | SFEBES2017

Salivary cortisol response to the short Synacthen® test provides a reliable alternative to serum measurement in the assessment of suspected hypoadrenalism

El-Farhan Nadia , Tennant Sarah , Lansdown Andrew , Evans Carol , Rees D Aled

Background: Serum total cortisol responses to the short Synacthen® test (SST) are used to confirm or refute a diagnosis of adrenal insufficiency. Salivary cortisol measurement offers a non-invasive alternative and has the potential advantage of evaluating free, bioavailable cortisol. However, reference ranges and its performance in the investigation of suspected hypoadrenalism (SH) have not been firmly established.Aims: 1....

ea0050p007 | Adrenal and Steroids | SFEBES2017

Salivary cortisol response to the short Synacthen® test provides a reliable alternative to serum measurement in the assessment of suspected hypoadrenalism

El-Farhan Nadia , Tennant Sarah , Lansdown Andrew , Evans Carol , Rees D Aled

Background: Serum total cortisol responses to the short Synacthen® test (SST) are used to confirm or refute a diagnosis of adrenal insufficiency. Salivary cortisol measurement offers a non-invasive alternative and has the potential advantage of evaluating free, bioavailable cortisol. However, reference ranges and its performance in the investigation of suspected hypoadrenalism (SH) have not been firmly established.Aims: 1....

ea0059p216 | Thyroid | SFEBES2018

Management of ‘Anomalous’ thyroid results

Souza Lezia D , Evans Carol , Lansdown Andrew , Rees D Aled , Premawardhana Lakdasa

Background/objectives: While patients are commonly referred to endocrinology with a low FT4 and normal TSH, there is no consistency in the management of these patients. The aim of this audit was to assess management of these patients including investigation, diagnosis and pharmacological intervention and compare to the current Association for Clinical Biochemistry guidelines.Methods: This was a retrospective audit studying 41 endocrine outpatients at Uni...

ea0031p38 | Clinical biochemistry | SFEBES2013

Development of an inductively coupled plasma-mass spectrometry method for measurement of urine iodine and assessment of iodine status in subclinical hypothyroidism

Jones Katie , Rogers Joanne , De Lloyd Anna , Rees Aled , Ludgate Marian , Evans Carol

Iodine deficiency may lead to reduced thyroid hormone production and ultimately hypothyroidism. The UK has previously been considered to be iodine sufficient, however recent evidence suggests the UK may be iodine deficient. Iodine status can be assessed in several ways, including measurement of urinary iodine excretion, for which inductively coupled plasma-mass spectrometry (ICP-MS) is considered the gold standard method.An ICP-MS method for determinatio...

ea0013p303 | Thyroid | SFEBES2007

W546X mutation of the thyrotropin receptor, cause of subclinical hypothyroidism (SH) in various clinical settings

Locantore Pietro , Evans Carol , Zhang Lei , Warner Justin , Gregory John , John Rhys , Lazarus John , Ludgate Marian

Objectives: Pregnancy and early infancy are periods when increased demand for thyroid hormone can result in subclinical hypothyroidism (SH). SH is frequently a prodrome to autoimmunity, but may be a compensation mechanism for an underlying genetic defect. The W546X mutation of the thyrotropin receptor (TSHR) is present at a frequency of 1 in 180 in a Caucasian population. We aimed to investigate whether W546X was the cause of SH presenting in pregnancy and early infancy.<p...

ea0038p22 | Clinical biochemistry | SFEBES2015

Effect of cortisol assay bias on the overnight dexamethasone suppression test: implications for the investigation of Cushing’s syndrome

Brixey-McCann Rachel , Tennant Sarah , Geen John , Armston Annie , Barth Julian H , Keevil Brian , Rees Aled , Evans Carol

Background: NEQAS data demonstrate a divergence in bias of cortisol immunoassays over the last 10 years. Despite this, a serum cortisol of 50 nmol/l has been universally applied as the cut-off for the overnight dexamethasone suppression test (ONDST), the commonest screening test for CushingÂ’s syndrome.Aims: To assess the effect of assay bias on interpretation of the ONDST and determine the necessity for a method-specific cut-off.<p class="abstex...