Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1571 | Thyroid (non-cancer) | ICEECE2012

An audit and patient satisfaction survey of the telephone endocrine clinic at University Hospital Lewisham, London

Mustafa O. , Gan J. , Evans K. , Mohandas C. , Miell J.

Introduction: The telephone endocrine clinic (TEC) was established as an adjunct to the face-to-face endocrine clinic to follow and monitor the progress in a selected group of patients after they were seen in main endocrine clinics. This model of care has been tried successfully in other specialities but not as widespread in endocrinology. We audited the effectiveness of TEC and patient satisfaction. Methods: A retrospective analysis of records of all patients contacted in TEC...

ea0031p5 | Bone | SFEBES2013

Mimicking osteocytes in vivo using 3D collagen gels: development of a novel tool to study osteocyte biology

Scully Nicole , Evans Sam L , Mason Deborah J , Evans Bronwen A J

Osteocytes make up >90% of bone cells, are embedded in mineralised matrix where they form a communication network. Osteocytes differentiate from osteoblasts, and are thought to be mechano-sensitive. They are very difficult to isolate leading to a dependence on cell lines for in vitro studies of osteocyte biology. There is thus a need to develop new methods to study these cells. Recent publications indicate that osteoblasts maintained in in vitro 3D collagen g...

ea0019p357 | Thyroid | SFEBES2009

Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination T4/T3 therapy in patients on thyroid hormone replacement

Panicker V , Saravanan P , Vaidya B , Evans J , Hattersley A , Frayling T , Dayan C

Introduction: There remains considerable debate over combination T4/T3 therapy for thyroid hormone replacement. Whilst large randomised-controlled studies have failed to show benefit over T4 only, there remain patients who feel better on the combination. Animal studies suggest that up to 80% of intracellular T3 in the brain is derived from circulating T4 by local deiodination. We hypothesized that in patients on thyroxine ...

ea0009oc10 | Oral Communication 2: Reproduction and growth | BES2005

Glucocorticoid-induced apoptosis in human decidua: a novel role for 11 beta-hydroxysteroid dehydrogenase in late gestation

Chan J , Evans K , Innes B , Bulmer J , Stewart P , Hewison M , Kilby M

Glucocorticoids (GCs) play a fundamental role in the endocrinology of pregnancy but excess GC in utero may lead to IUGR. Protection against fetal exposure to GCs is provided by the enzyme 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2) located in the placental trophoblast. By contrast, relatively little is known concerning the function of GC-activating 11beta-HSD1 which is expressed within maternal decidua. We have used human deciduas (n=32 first, n=10 second and n=...

ea0005p258 | Thyroid | BES2003

The W546X mutation of the thyrotropin receptor gene: Potential major contributor to thyroid dysfunction in a caucasian population

Jordan N , Willliams N , Gregory J , Evans C , Owen M , Ludgate M

Congenital hypothyroidism (CH) occurs in approximately 1 in 3000 individuals. Rapid detection and treatment by neonatal screening and administration of T4, is essential to prevent severe mental retardation and impaired growth.We report on two Welsh siblings, detected by neonatal screening, which had normal sized and placed glands but negative isotope uptake. Mutations resulting in CH are known to occur in 11 known genes, given the clinical presentation, we investigated the...

ea0003p295 | Thyroid | BES2002

Molecular characterisation of congenital hypothyroidism

Jordan N , Gregory J , Evans C , Williams N , Owen M , Ludgate M

Congenital hypothyroidism (CH) occurs in approximately 1 in 3000 individuals. Rapid detection by neonatal screening and T4 administration is essential to prevent severe mental retardation and impaired growth. About one third of CH is due to mutations in known genes including the thyrotropin receptor (TSHR).Two Welsh male siblings with CH were detected, both had normally sized and located thyroid glands, no iodide uptake and were negative for thyroid bloc...

ea0029oc17.5 | Diabetes Basic | ICEECE2012

Glucocorticoid receptor α expression is downregulated in gluteal subcutaneous adipose tissue of black South African women and associates with increased metabolic risk

Goedecke J. , Stimson R. , Livingstone D. , Hayes P. , Adams K. , Dave J. , Keswell D. , Evans J. , Victor H. , Lambert E. , Levitt N. , Kahn S. , Olsson T.

Introduction: Increased capacity for glucocorticoid regeneration in subcutaneous adipose tissue (SAT) by 11β-hydroxysteroid dehydrogenase-1 (11HSD1) is associated with obesity and associated risk factors. We hypothesised that down-regulation of SAT 11HSD1 and/or glucocorticoid receptor-α (GRα) may explain differences in body fat distribution and metabolic risk between black and white women. The study aimed to compare the expression of 11HSD1 and glucocorticoid r...