Searchable abstracts of presentations at key conferences in endocrinology

ea0031p5 | Bone | SFEBES2013

Mimicking osteocytes in vivo using 3D collagen gels: development of a novel tool to study osteocyte biology

Scully Nicole , Evans Sam L , Mason Deborah J , Evans Bronwen A J

Osteocytes make up >90% of bone cells, are embedded in mineralised matrix where they form a communication network. Osteocytes differentiate from osteoblasts, and are thought to be mechano-sensitive. They are very difficult to isolate leading to a dependence on cell lines for in vitro studies of osteocyte biology. There is thus a need to develop new methods to study these cells. Recent publications indicate that osteoblasts maintained in in vitro 3D collagen g...

ea0034p166 | Growth and development | SFEBES2014

Differential effects of grazing and meal feeding on skeletal growth and femoral strength in male rats

Tilston Thomas W , Hopkins Anna L , Brown Richard C , Arms-Williams Bradley , Evans Sam L , Wells Timothy

The pattern of food consumption has a profound influence on metabolic hormone secretion, but until recently only crude manipulations of feeding events have been possible in rodents. Using a CLAMS-based system to overcome this problem, we have investigated the effect of 3 weeks of grazing (consumption of 1/24th of the total daily food intake of ad libitum-fed controls every 30 min during the dark phase (18.00–06.00 h)) and meal feeding (three 1-h periods of ad...