Searchable abstracts of presentations at key conferences in endocrinology

ea0071030 | A rare ABCC8 gene mutation causing severe Maturity-Onset Diabetes of the Young (MODY-12): case report and mini review | BES2020

A rare ABCC8 gene mutation causing severe Maturity-Onset Diabetes of the Young (MODY-12): case report and mini review

Marijke Timmers , Eveline Dirinck , Patrick Lauwers , Christophe De Block

Context: Maturity-Onset Diabetes of the Young (MODY) refers to a group of monogenic β cell disorders1. MODY12 comprises various mutations in the ATP-binding cassette transporter subfamily C member 8 (ABCC8) gene of the ATP-sensitive potassium (K-) channel and is a condition that is not frequently encountered, comprising 1% of all MODY types1. Gain-of-function ABCC8 mutations can result in neonatal diabetes mellitus and/or MODY12, whereas loss-of-fun...

ea0073aep11 | Adrenal and Cardiovascular Endocrinology | ECE2021

The role of estimated glucose disposal rate as a predictor of insulin resistance, NAFLD and major adverse cardiovascular events in type 1 diabetes mellitus

Mertens Jonathan , Block Christophe De , Dirinck Eveline , Francque Sven

Background and AimsPeople with type 1 diabetes (T1D) have an increased risk of cardiovascular disease (CVD) despite insulin therapy to treat hyperglycaemia. Insulin resistance may be a contributing factor to CVD. Insulin resistance is strongly associated with NAFLD, which is increasingly linked to CVD. The estimated glucose disposal rate (eGDR) correlates well with the euglycemic clamp, which is the gold standard to assess insulin resistance in T1D, but ...

ea0079014 | Abstracts | BES2021

Estimated glucose disposal rate, non-alcoholic fatty liver disease and micro- and macrovascular complications in type 1 diabetes: Towards a new biomarker?

Jonathan Mertens , Jonas Weyler , Luisa Vonghia , Wilhelmus Kwanten , Eveline Dirinck , Sven Francque , Christophe De Block

Background and aims: Insulin resistance is increasingly prevalent in patients with type 1 diabetes (T1D). Insulin resistance is associated with both cardiovascular complications and non-alcoholic fatty liver disease (NAFLD), but its assessment is challenging in T1D due to the technical difficulties of the euglycaemic clamp technique. The estimated glucose disposal rate (eGDR) is a validated alternative to quantify insulin resistance in T1D, but its role in clinical practice is...

ea0081rc10.1 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Insulin resistance as indexed by the estimated glucose disposal rate and liver fat content are correlated in type 1 diabetes

Mertens Jonathan , Spinhoven Maarten , Dirinck Eveline , Vonghia Luisa , Francque Sven , De Block Christophe

Introduction: The prevalence of metabolic syndrome is increasing in individuals with T1D, which could potentiate the development of NAFLD. The pathophysiology of NAFLD in T1D is still unclear, due to the co-existence of predisposing and protective factors. Insulin resistance (IR) is theorized as a key driver of NAFLD.Aim: We investigated the association between liver fat content (LFC), NAFLD, and IR in individuals with T1D. Subjects underwent magnetic re...

ea0070aep304 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Diagnostic accuracy of fatty liver index in type 1 diabetes mellitus patients

Mertens Jonathan , Eveline Dirinck , Jonas Weyler , Luisa Vonghia , Sven Francque , Christophe De Block

Introduction: Nonalcoholic fatty liver disease (NAFLD) affects ±55% of subjects with type 2 diabetes and contributes to cardiovascular mortality. NAFLD data in type 1 diabetes (T1DM) are scarce. Biopsy is the diagnostic reference but is not suited for routine screening. Ultrasound (US) is validated to diagnose steatosis as first-line imaging but is restricted to trained operators. The Fatty Liver Index (FLI) is a score to predict fatty liver based on triglycerides, Body M...

ea0073aep157 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Lipid accumulation product can accurately rule out, but not rule in non-alcoholic fatty liver disease in type 1 diabetes

Mertens Jonathan , Dirinck Eveline , Vonghia Luisa , Francque Sven , Block Christophe De

IntroductionLipid accumulation product (LAP), an index based on waist circumference (WC) and serum triglyceride levels, is associated with the presence and severity of non-alcoholic fatty liver disease (NAFLD). However, its potential as a risk marker of NAFLD in subjects with type 1 diabetes (T1D) has not been studied yet.AimsThis study evaluated the ability of LAP to estimate the presence of NAFLD in adults ...

ea0073aep203 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Is there an association between sex steroids and biopsy-proven non-alcoholic fatty liver disease in obese men? A cross-sectional analysis of 134 men

Herdt Carlien De , Block Christophe De , Kristof Van Dessel , An Verrijken , Francque Sven , Dirinck Eveline

Background and aimsLow levels of testosterone and non-alcoholic fatty liver disease (NAFLD) in obese men are both linked to the metabolic syndrome, but the independent association between testosterone and NAFLD needs to be elucidated. In this cross-sectional analysis the association between total testosterone (total T) and calculated free testosterone (cFT) on the one hand and NAFLD, non-alcoholic steatohepatitis (NASH) and fibrosis on the other hand was...

ea0075o03 | Obesity, metabolism & miscellaneous endocrinology | EYES2021

The estimated glucose disposal rate as a potential biomarker for non-alcoholic fatty liver disease and cardiovascular disease in type 1 diabetes

Mertens Jonathan , Weyler Jonas , Vonghia Luisa , Dirinck Eveline , Francque Sven , De Block Christophe

Background: Patients with type 1 diabetes (T1D) have an increased risk of cardiovascular disease (CVD), despite insulin therapy. Insulin resistance is strongly associated with non-alcoholic fatty liver disease (NAFLD) and CVD. The euglycemic clamp, the gold standard to assess insulin resistance in T1D, is unsuited for clinical practice. The estimated glucose disposal rate (eGDR) is increasingly used as an alternative in T1D, but its role as a NAFLD or CVD predictor is unexplor...

ea0079008 | Abstracts | BES2021

Fast-acting insulin aspart improves glucose control in a real-world setting: a 1-year multicenter study in people with type 1 diabetes using continuous glucose monitoring

Lisa Billion , Sara Charleer , Laurens Verbraeken , Mira Sterckx , Kato Vangelabbeek , Block Nathalie De , Charlien Janssen , Dessel Kristof Van , Eveline Dirinck , Frida Peiffer , Nancy Bolsens , Chantal Mathieu , Pieter Gillard , Christophe De Block

Background and Aims: To evaluate whether switching from traditional mealtime insulin analogs to fast-acting insulin aspart (Fiasp) in routine clinical practice is efficacious and safe in adult people with type 1 diabetes (PWD1) using intermittent or real-time continuous glucose monitoring (iCGM or rtCGM).Methods: Data from 438 adult PWD1 (60% men, age 44.6±16.1 years, duration of diabetes 21.5±14.0 years, iCGM/rtCGM: 391/47, injections/pump: 409/29...