Searchable abstracts of presentations at key conferences in endocrinology

ea0011p28 | Bone | ECE2006

Evidence for high prevalence of hormonal irregularities in male osteoporosis

Goebel S , Riegel C , Seefried L , Saller B , Jakob F

Introduction: Osteoporosis in males is an underdiagnosed condition. It is considered to be of secondary pathogenesis in up to 60% of cases. In order to establish rational flow charts for the diagnosis and management of osteoporosis in men solid data seem to be necessary about the incidence of certain underlying diseases.Methods: In a prospective screening for hormonal alterations we analysed 65 patients with male osteoporosis according to laboratory para...

ea0011p45 | Bone | ECE2006

Expression of the membrane-associated hormone-sensitive protein UO-44 in hMSC-TERT immortalized mesenchymal stem cells

Seefried L , Ebert R , Kassem M , Jakob F

UO-44 is a novel protein of unknown function which was described in uterus, medium-size ovarian follicles, oviduct and pancreas of different mammalian species. Using differential display analysis in preimplantation rat uteri, Chen et al. 1999 cloned and described it as an estradiol responsive gene named estrogen regulated gene 1 (ERG-1). Subsequent characterization showed that its expression was modified through pregnancy. The human ortholog (HuUO-44) was cloned and cha...

ea0011p44 | Bone | ECE2006

Selenium supplementation restores the antioxidative capacity and prevents cell damage in mesenchymal stem cells in vitro

Ebert R , Ulmer M , Zeck S , Meissner-Weigl J , Schneider D , Stopper H , Schupp N , Kassem M , Jakob F

Mesenchymal stem cells (MSC) are developed for cell based therapeutic strategies and undergo cellular stress during ex vivo procedures. Reactive oxygen species (ROS) of environmental and cellular origin are involved in redox signaling, cumulative cell damage, senescence and tumor development. Selenium independent (superoxide dismutases 1 and 2 (SOD1 and SOD2) and catalase (CAT)) and selenium dependent (glutathione peroxidases (GPx), thioredoxin reductases (TrxR)) enzyme...