Searchable abstracts of presentations at key conferences in endocrinology

ea0081p526 | Adrenal and Cardiovascular Endocrinology | ECE2022

Testosterone, hypogonadism, and heart failure: a systematic and critical review

Di Lodovico Elena , Facondo Paolo , Delbarba Andrea , Chiara Pezzaioli Letizia , Maffezzoni Filippo , Cappelli Carlo , Ferlin Alberto

Background: Male hypogonadism is defined by low circulating testosterone level associated with signs and symptoms of testosterone deficiency. Although the bidirectional link between hypogonadism and cardiovascular disease has been clarified recently, the association between testosterone and chronic heart failure (CHF) is more controversial. Methods: We critically review published studies relating to testosterone, hypogonadism, and CHF and provide practic...

ea0081p441 | Reproductive and Developmental Endocrinology | ECE2022

Usefulness of routine assessment of free testosterone for the diagnosis of functional male hypogonadism

Facondo Paolo , Di Lodovico Elena , Chiara Pezzaioli Letizia , Cappelli Carlo , Ferlin Alberto , Delbarba Andrea

Objective: To investigate whether routine assessment of free testosterone improves the diagnostic accuracy of functional male hypogonadism.Methods: Total and free testosterone (calculated through SHBG assessment) were determined in 372 male patients (median age 44) referring to our department for sexual symptoms symptoms (188 patients) or infertility (184 men). Low total and free testosterone were defined as < 2.31 ng/ml and <63 pg/ml, respective...

ea0070aep805 | Reproductive and Developmental Endocrinology | ECE2020

Hypogonadism and testis impairment in patients with amyloidosis due to Apo A-I Leu75Pro mutation

Facondo Paolo , Delbarba Andrea , Chiara Pezzaioli Letizia , Di Lodovico Elena , Cappelli Carlo , Scolari Francesco , Ferlin Alberto

Introduction: Amyloidosis due to Apo A-I Leu75Pro mutation is a rare form of hereditary amyloidosis with systemic involvement mainly of testicle, kidney and liver. This disease finds a wide prevalence in the province of Brescia (Northern Italy), which represents a geographic uniqueness for the spread of this amyloidosis form. Somefeatures of this disease have not yet been described.Purpose: To describe the frequency of organ damages in this amyloidosis f...

ea0081p299 | Calcium and Bone | ECE2022

Impact of body composition on skeletal health in subjects with Klinefelter’s syndrome: a cross sectional study

Carrone Flaminia , Vena Walter , Delbarba Andrea , Chiara Pezzaioli Letizia , Facondo Paolo , Cappelli Carlo , Pizzocaro Alessandro , Mazziotti Gherardo , Lania Andrea Gerardo , Ferlin Alberto

Background: There is growing awareness of skeletal impairment in individuals with Klinefelter syndrome (KS), involving both quantitative and qualitative alteration of the bone as well as an increased prevalence of vertebral fractures (VFs). Beyond hypogonadism, considerable evidence suggests that other factors may be responsible for the skeletal fragility observed in these patients. Abnormal body composition is a common finding in KS subjects, characterized by an unfavourable ...

ea0070aep145 | Bone and Calcium | ECE2020

Prevalence of osteoporosis, vertebral fractures and hypogonadism in HIV-infected men.

Chiara Pezzaioli Letizia , Porcelli Teresa , Maffezzoni Filippo , Facondo Paolo , Di Lodovico Elena , Delbarba Andrea , Properzi Martina , Cappelli Carlo , Castelli Francesco , Eugenia Quiros Roldan Maria , Ferlin Alberto

With HAART (Highly Active Anti-Retroviral Therapy) introduction, HIV infection history has radically changed. Increased survival has led to new complications, including osteoporosis. The pathogenesis of osteoporosis in HIV patients is multifactorial: virus, HAART, smoking, alcohol, physical inactivity, comorbidities, and hypogonadism can interact in bone depletion.Aim of this study was to evaluate the prevalence of osteoporosis, vertebral fractures (VF) ...