Endocrine Abstracts

Introduction: The effects of finasteride on insulin resistance and of metformin on hyperandrogenism in patients with polycystic ovary syndrome (PCOS) are not clear. This study therefore compared the effects of finasteride, metformin, and finasteride plus metformin treatments on hormone levels, insulin resistance, and hirsutism score in women with PCOS.Subjects and method: Fifty-two patients with PCOS were randomly assigned to receive finasteride 5 mg/day...

Methods: This study, was a cross-sectional survey. Sampling design was based upon multistage probability sampling. Patient with diabetes, hypertension, cardiovascular diseases and any other diseases were excluded from the study. Age and gender were noted. Heights, weights and waist circumference (WC) were measured. BMI was calculated. Blood pressure (BP) was measured. Fasting thyrigliseride levels were evaluated. Patients were divided into two groups according to their triglyc...

Introduction: We aimed to investigate the homeostasis model assessment of insulin resistance (HOMA-IR) and relation of HOMA-IR with age, sex and body mass index (BMI) and the prevalence of diabetes in Turkish population of different regions.Methods: Cross-sectional observational study was done in the frame of Turkish prevalence of insulin resistance multicenter study. The study sample consisted of volunteers from seven different regions of Turkey. Weight...

Introduction: Idiopathic hypogonadotropic hypogonadism (IHH) is a rare disorder characterised by delayed or absent sexual maturation and infertility associated with inappropriately low gonadotropin and sex steroid levels. Insulin resistance (IR) is defined as an impaired biologic response to both endogenous and exogenous insulin. IR is a common precursor to the development of glucose intolerance, including diabetes, hypertension, and cardiovascular disease. Dyslipidaemia, apol...

Objectives: Hypogonadism is associated with a higher risk of atherosclerosis and cardiovascular disease, but the mechanisms underlying this association are not yet fully understood. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. We aimed to determine serum PON1 activities, an established lipid antioxidant, MDA levels which are end products of lipid peroxidation induced by ROS and thiol groups as an antioxidant fo...

Objective: GH deficiency is associated with an increased cardiovascular mortality. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. In the present study, we aimed to determine i) serum PON1 activities, an established lipid antioxidant, ii) MDA levels which are end products of lipid peroxidation induced by ROS and iii) thiol groups as an antioxidant for evaluating oxidative stress in patients with GHD before and aft...

Aim: Acromegaly is an endocrine disorder characterized by sustained elevation of circulating GH and insulin-like growth factor (IGF1). IGF1 is a potent mitogen and has a role in the transformation of normal cells to malignant cells. Micronucleus (MN) frequency is a biomarker of chromosomal damage, genome instability and cancer risk. Our study aimed to evaluate spontaneous MN frequency by using the cytokinesis block MN assay to determine genetic damage in lymphoytes of patients...

Objective: Vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 1 (VEGFR1) are known to be related to thyroid tumorigenesis, but data are limited about their relationship with insulin like growth factor 1 (IGF1) and IGF1 receptor. The aim of this study was to clarify the role of VEGF, VEGFR-1, IGF1 and IGF1 receptor in thyroid tumorigenesis.Methods: We examined 40 patients with differentiated thyroid carcinoma (DTC) a...

Although the existence of the interaction between sex steroids and immune system is well known, the mechanisms of this interaction are still unclear. Recently a second form of GnRH (GnRH-II) has been described in human, which is significantly expressed in immune tissues suggesting a potential function. In a recent in-vitro study it has been demonstrated that GnRH-II decreases local expression of IL-2R in peripheral lymphocytes (1). However in-vivo interactions of...

Objective: Establishing good metabolic control is essential to prevent morbidity and mortality in patients with type 2 diabetes (T2DM). This nationwide survey is performed five years after the first national TEMD study, to search for any improvement in attaining glycemic and metabolic targets in Turkish patients with T2DM.Methods: The nationwide, multicenter survey consecutively enrolled patients who were under follow up for at least a year in tertiary c...