Endocrine Abstracts

Aim: Our previousstudies have shown evidence for insulin-releasing actions of some amphibian skin peptides; including esculentin-2CHa. However, there is a need to further improve the potency of some of this peptides and to characterize their other beneficial effects. This study investigates the effect of a Leu31→Lys substitution on the insulin-releasing and immunomodulatory effects of esculentin-2CHa.Methods: BRIN-BD11 cells were incubat...

Aim: Insulin-releasing effects and potential anti-diabetic actions of peptides isolated from the skin secretion of the African clawed frog, Xenopus amieti has been reported. However, peptides such as magainin-AM1 has not been previously studied for its ability to stimulate insulin secretion or promote glucose uptake. This study investigated insulin releasing effects as well as possible underlying mechanisms.Methods: Acute and chronic actions of ...

Aim: Beneficial effects of Jatropha tanjorensis (J. tanjorensis) extracts in African traditional medicinal practices for the management of type 2 diabetes have been reported. However, mechanisms through which these extracts exert their anti-diabetic actions have not been widely studied.Methods and materialsEffects of various aqueous extracts of root, leaf, and bark J. tanjorensis (0-1000 μg/ml) on insulin-release, cytotoxicity and cell viability were investigated using BR...

1=School of Sciences, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK 2= Department of Biochemistry, Obafemi Awolowo University, Ile-Ife, Nigeria3= IRiD Biosciences, Wilding Road, Ball Green, Stoke-on-Trent, ST6 8BQAim: Vernonia amygdalina extract is used traditionally for type 2 diabetes treatment in developing countries. Studies have reported antidiabetic properties of aqueous...

Aim: Gallic acid is one of the major bioactive phenolic compounds that have been isolated from several plant extracts with reported antidiabetic actions. However, insulinotropic effects and mechanisms underlying antidiabetic actions of garlic acid is poorly understood. This study investigated insulin-releasing and glucose-lowering effects of gallic acid.Methods: Glucose-stimulated insulin secretion in BRIN-BD11 cells were examined in the absence or prese...

Aim: Ocimum basilicum extract is used traditionally for type 2 diabetes treatment in developing countries. Studies have reported antidiabetic properties of aqueous and methanolic extracts of O. basilicum but mechanisms underlying these actions are not fully understood.Methods: Insulin-releasing effect of O. basilicum extract (0.1 – 1000µg/ml) were investigated using BRIN-BD11 cells. Effects of the extract (100µg/...

Aim: The use of commonly consumed vegetables, such as Pterocarpus mildbraedii, in the treatment of metabolic conditions is consistent with the food-as-medicine strategy. To characterise its pharmacological actions, this study assessed insulin-releasing and glucose lowering effects of effects of P. mildbraedii in models of type 2 diabetes.Methods: Clonal pancreatic cells, BRIN-BD11, were treated P. mildbraedii extracts...