Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep702 | Pituitary: basic and neuroendocrinology | ECE2015

Molecular analysis of miRNA expression profiles in AIP mutation positive somatotropinomas

Falk Nikolai , Daly Adrian , Beckers Albert , Pellegata Natalia

Germline mutations in the aryl hydrocarbon receptor interacting protein gene (AIP) predispose to pituitary adenomas in young patients, often presenting as familial isolated pituitary adenoma (FIPA) kindreds. Pituitary adenomas in patients with AIP mutations (AIPmut) are usually somatotropinomas, which are more aggressive and have poorer responses to somatostatin analogues than their non-mutated counterparts. Given the rarity of this condition, the molecular pathogenesis of the...