Searchable abstracts of presentations at key conferences in endocrinology

ea0059oc5.6 | Adrenal | SFEBES2018

Therapeutic glucocorticoids prevent local and systemic bone loss in the TNF-tg model of chronic inflammatory disease

Fenton Chloe , Fareed Syeda , Naylor Amy , Nanus Dominika , Cooper Mark , Raza Karim , Lavery Gareth , Hardy Rowan

Both therapeutic glucocorticoids (GCs) and chronic inflammation are powerful inducers of systemic bone loss, resulting in osteoporosis and increased morbidity. Whilst GCs suppress inflammation, it is unclear how these factors interact to determine net bone metabolism. We investigated the balance between osteo-protective and osteo-destructive properties of GCs in the TNF-tg model of chronic inflammatory disease. Wild-type (WT) and TNF-tg mice were treated with corticosterone (1...

ea0059p032 | Adrenal and steroids | SFEBES2018

Glucocorticoid activation by 11β-HSD1 is increased in M1, but not M2 polarised macrophages, where it determines pro-inflammatory cytokine expression

Martin Claire S , Garcia Amadeo Munoz , Fenton Chloe , Fareed Syeda , Hewison Martin , Hardy Rowan

In chronic inflammatory disease, an increased proportion of M1 polarised macrophages have been shown to contribute to inflammation and tissue damage through the production of pro-inflammatory cytokines such as TNFα. Previously, we have identified expression of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive glucocorticoids (GCs) to their active counterparts, in M1 polarised macrophages in vivo. We hypothesised that 11β...