Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep763 | Pituitary: clinical | ECE2015

When the improbable happens: a case of acromegaly diagnosed during pregnancy

Faria Carolina , Guerra Silvia , Mascarenhas Mario

Introduction: Pregnancy in a patient with acromegaly is uncommon, as the enlarging pituitary adenoma suppresses gonadotropin secretion rendering the patient amenorrhoeic and infertile. About 40% of the women with pituitary adenomas also have hyperprolactinaemia, which further decreases the likelihood of pregnancy.Case report: A 32-year-old woman was sent to our centre in the first trimester of pregnancy with the diagnostic of gestational diabetes. Clinic...

ea0049gp237 | Thyroid Cancer & Thyroid Case Reports | ECE2017

Thyrotoxic Periodic Paralysis due to Graves’ disease: a mandatory differential diagnosis in Asian patients presenting with paralysis and hypokalemia

Barbosa David , Faria Carolina , Osorio Ana Sofia , Nobre Ema , Vilas Ana Paula , Bugalho Maria Joao

Introduction: Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of hyperthyroidism that is underdiagnosed and frequently missed. It is relatively common in Asian men with Graves’ disease. TPP attacks are frequently associated with hypokalemia.Case presentation: We describe a 26-year-old Asian male with an unremarkable past medical history who was admitted following sudden onset of flaccid paralysis of the lower extre...

ea0049gp239 | Thyroid Cancer & Thyroid Case Reports | ECE2017

Renal cell carcinoma metastasis to thyroid tumor: a case report

Faria Carolina , Barbosa David , Osorio Ana Sofia , Nobre Ema , Bugalho Maria Joao

Introduction: Subacute thyroiditis (SAT) association with papillary thyroid carcinoma (PTC) has been rarely reported in the literature. Metastatic neoplasms to the thyroid are rare in clinical practice. Renal cell carcinomas (RCC) are the most frequent site of origin of thyroid metastases (12 to 34%). Tumor-to-tumor metastases, in which a thyroid neoplasm is the recipient of a metastasis, are exceedingly rare. Tuberous sclerosis (TS) is associated with several renal manifestat...

ea0049ep95 | Adrenal medulla | ECE2017

Biochemical testing for pheochromocytoma

Faria Carolina , Barbosa David , Osorio Ana Sofia , Nobre Ema , Sampaio Joaquim , Bugalho Maria Joao

Introduction: Biochemical testing for Paraganglioma/Pheochromocytoma (PGL/PHEO) is recommended in patients with classical symptoms, in those harbouring an adrenal incidentaloma and in patients who have a hereditary risk for developing a PGL/PHEO. Measurements of plasma free metanephrines and/or urinary fractionated metanephrines provide a highly sensitive test for diagnosis but false-positive results remain a problem.Aim: Comparative analysis of plasma a...

ea0049ep320 | Clinical case reports - Thyroid/Others | ECE2017

Parathyroid nodular hyperplasia: when imaging exams fail

Osorio Ana Sofia , Rocha Jose , Faria Carolina , Barbosa David , Nobre Ema , Bugalho Maria Joao

Introduction: Parathyroid hyperplasia is the second cause of primary hyperparathyroidism (PH), representing 15–20% of all cases. The scintigraphy with Tc-99m-Sestamibi is a preoperative exam used to identify parathyroid adenomas or hyperplasia. It has a sensibility of 50–90%, which increases with larger parathyroid size. The neck ultrasonography (US) has also an important role detecting parathyroid enlarged glands with 70% sensibility. We report a case of parathyroid...

ea0049ep1037 | Pituitary - Clinical | ECE2017

Pituitary Stalk Hemangioblastoma: a case report and review of the literature

Barbosa David , Faria Carolina , Osorio Ana Sofia , Nobre Ema , Bugalho Maria Joao

Introduction: Hemangioblastomas (HBL) in the pituitary stalk are extremely rare. Most pituitary stalk HBL reported in the literature were associated with von Hippel–Lindau (VHL) disease.Case report: We report the case of a 34-year-old female patient with VHL disease diagnosed at the age of 18 with multiple complications (bilateral retinal and cerebellum HBL, renal cell carcinoma). Brain magnetic resonance imaging (MRI) demonstrated an hypointense su...

ea0049ep1085 | Clinical case reports - Pituitary/Adrenal | ECE2017

CHARGE Syndrome: a rare case of hypogonadotropic hypogonadism

Osorio Ana Sofia , Faria Carolina , Barbosa David , Nobre Ema , Bugalho Maria Joao

Introduction: CHARGE Syndrome (CS) is a rare cause of hypogonadotropic hypogonadism (HH), usually diagnosed in paediatric age when pubertal development is compromised. Herein, we report a case that presented a major criterion and three minor criteria.Case report: At age ten, the patient was referred to the paediatric endocrinology unit due to phenotypic alterations and psychomotor and cognitive impairment. She had no family history of consanguinity, inhe...

ea0049ep1340 | Thyroid (non-cancer) | ECE2017

Peripheral neuropathy in hypothyroidism - about a clinical case

Marcalo Jose , Araujo Alexandra , Faria Carolina , Wessling Ana , Carvalho Maria Raquel , Nobre Ema , Bugalho Maria Joao

Introduction: Hypothyroidism can affect the nervous system, commonly causing mono and polyneuropathies which show a variable frequency and pattern. Its mechanisms are not fully understood. Symptoms usually correlate better with the duration of the dysfunction rather than with its severity and typically improve significantly after medical therapy.Case report: A 58-year-old woman was admitted at our hospital with a one-year history of progressive weakness ...

ea0037ep611 | Obesity and cardiovascular endocrinology | ECE2015

C-reactive protein assay in obese paediatric patients: comparison of two laboratory methods

Alves Jose , Manacas Marta , Faria Carolina , Filipe Lia , Silva Susana , Proenca Helena

Introduction: Obesity as a pro-inflammatory state is associated to increased levels of C-reactive protein (CRP). CPR is considered as a cardiovascular (CV) risk independent marker and is being researched as a predictive atherosclerosis biomarker in obese children. The American Heart Association (AHA) recommends a three classes approach when aiming at CV risk stratification (low <1.0 mg/l; moderate 1.0–3.0 mg/l; and high >3.0 mg/l). These classes were extrapolated ...

ea0049ep1133 | Female Reproduction | ECE2017

Influence of thyroid stimulating hormone (TSH) level in in-vitro fertilization (IVF) success

Faria Carolina , Gomes Ana , Nunes Joaquim , Sousa Sandra , Ana Aguiar , Catia Rodrigues , Joaquim Sampaio , Carlos Calhaz-Jorge

Introduction: Prevalence of hypothyroidism is 2–5% in women in the reprodutive age group. Hypothyroidism can affect fertility due to anovulatory cycles, luteal phase defects, hyperprolactinemia and sex hormones imbalance. Some data also report that TSH levels are inversely proportional to the fertilization rate at ART (assisted reproductive technologies).Objective: To evaluate if a relationship exists between pregnancy rates in women undergoing ...