Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1448 | Thyroid (non-cancer) | ECE2017

Impact of RAC1/1b signalling on Sodium Iodide symporter regulation

Faria Marcia , Matos Paulo , Bugalho Maria Joao , Silva Ana Luisa

The Sodium Iodide Symporter (NIS) is responsible for active transport of iodide into thyroid cells. Its expression in thyroid tumors allows the use of radioactive iodine (131I) as co-adjuvant therapeutic tool to eliminate remaining tumor cells and metastases after total thyroidectomy. Nevertheless, certain subsets of patients with advanced forms of thyroid cancer lose the ability to respond to radioiodine therapy, which drastically reduces their survival rates. Recent studies ...