ea0044p35 | Adrenal and Steroids | SFEBES2016
Farraj Layal Abi
, Morgan Michael
, Alase Adewonuola
, Carr Ian
, Stewart Paul
, Tiganescu Ana
Glucocorticoids (GC) drive multiple adverse effects in skin e.g. epidermal thinning, dermal atrophy and impaired wound healing (WH). Our previous findings indicate increased expression of the GC-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in primary human dermal fibroblasts (HDF), full-thickness skin from older donors and during the inflammatory phase of mouse skin WH. We also reported protection from age-induced dermal atrophy and improved W...