Searchable abstracts of presentations at key conferences in endocrinology

ea0022p429 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Ectopic Cushing’s syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum

Singer Joerg , Koch Christian A , Bartels Michael , Aigner Thomas , Lincke Thomas , Fasshauer Mathias , Paschke Ralf

CushingÂ’s syndrome can be caused by adrenocorticotropic hormone-secreting solid tumors. We report a rare case of an ileal endocrine carcinoma that produced ACTH and induced hypercortisolism. A now 47-year-old male patient presented at the age of 41 with perspiration, weight gain, tremor and general fatigue. Diabetes mellitus and hypercortisolism was diagnosed by laboratory testing. Further examinations revealed ectopic CushingÂ’s syndrome. The search for the location ...

ea0016oc6.7 | Metabolism and cardiovascular | ECE2008

The mineralocorticoid receptor induces pro-inflammatory effects in white adipocytes and is essential for adipogenesis

Hoppmann Julia , Perwitz Nina , Fasshauer Mathias , Hadaschik Dirk , Lehnert Hendrik , Klein Johannes

Selective enhancement of glucocorticoid action in adipose tissue has been shown to induce characteristic features of the metabolic syndrome. Adipocyte-derived factors provide a link between altered adipose tissue mass and function and cardiovascular disease. However, key mechanisms controlling these pathophysiological alterations in adipose tissue are poorly understood. Recently, both, the glucocorticoid (GR) and the mineralocorticoid receptor (MR), have been shown to mediate ...

ea0016p509 | Obesity | ECE2008

Interleukin-1sz is a positive regulator of TIARP/STAMP2 in 3T3-L1 adipocytes

Sommer Grit , Kralisch Susan , Weise Sebastian , Ulrike Lossner , Matthias Bluher , Michael Stumvoll , Mathias Fasshauer

Tumor necrosis factor alpha-induced adipose-related protein (TIARP)/six-transmembrane protein of prostate 2 (STAMP2) has been characterized as an adipocyte-expressed protein which might play a crucial role in metabolic homeostasis and inflammatory pathways. In the current study, the impact of insulin resistance-inducing and proinflammatory interleukin (IL)-1ß on TIARP/STAMP2 gene expression was determined by quantitative real-time reverse transcription-polymerase chain re...