Searchable abstracts of presentations at key conferences in endocrinology

ea0056gp66 | Cardiovascular | ECE2018

Evaluation of irisin levels in chronic heart failure with preserved or reduced ejection fraction

Mancini Antonio , Silvestrini Andrea , Bruno Carmine , Vergani Edoardo , Brunetti Alessandro , Favuzzi Angela Maria Rita , Guidi Francesco , Meucci Elisabetta , Mordente Alvaro

Background: The recently discovered myokin Irisin, a peptide originated by a proteolytic cleavage of the transmembrane protein fibronectin type III domain containing 5 (FNDC5) whose expression is induced by exercise and/or by increasing peroxisome proliferator-activated receptor (PPAR)-γ co-activator 1α (PGC-1α), has been considered a prognostic factor in Chronic Ischemic Cardiomyopathy and Acute Heart Failure. Nevertheless, no data are available on Irisin level...

ea0056p626 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Multi-hormonal deficits in heart failure with preserved ejection Fraction: prevalence and impact on diastolic dysfunction

Bruno Carmine , Favuzzi Angela Maria Rita , Vergani Edoardo , Venuti Angela , Nicolazzi Maria Anna , Fuorlo Mariella , Landolfi Raffaele , Mancini Antonio

Background: In heart failure with reduced ejection fraction (HFrEF), catabolic mechanisms have a strong negative impact on morbidity and mortality. The relationship between anabolic hormonal deficit, thyroid function and heart failure with preserved ejection fraction (HFpEF) has still been poorly investigated. For this reason, we tried to define the prevalence of multi-hormonal deficiencies in HFpEF patients and the relationships between hormonal deficits and echocardiographic...