Searchable abstracts of presentations at key conferences in endocrinology

ea0020p520 | Paediatric Endocrinology | ECE2009

Mild hypothyroidism in children with congenital heart malformations

Passeri Elena , Ermetici Federica , Carminati Massimo , Costa Elena , Fugazzola Laura , Persani Luca , Ambrosi Bruno , Corbetta Sabrina

Congenital hypothyroidism is frequently associated with congenital cardiac malformations (CCM). Studies in knock-out mice showed that heart and great vessels organogenesis share some nuclear transcription factors with the embryonic thyroid, suggesting that thyroid defects may have a higher prevalence in children with CCM. The present study investigated thyroid function and morphology in 280 children (145 M/135 F, aged 0.3–12 years), affected by CCM (septal defects, ductus...

ea0020p585 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Genetic alterations of phosphodiesterase 11A (PDE11A) in acromegalic patients

Peverelli Erika , Ermetici Federica , Filopanti Marcello , Lania Andrea , Ferrero Stefano , Beck-Peccoz Paolo , Spada Anna

Background: Aberrant cAMP signalling is involved in the pathogenesis of somatotropinomas. Recently, variants of phosphodiesterase type 11A (PDE11A) gene have been described in patients with adrenocortical tumors. Aim of the study was to investigate the presence of these variants in patients with somatotropinomas.Subjects and methods: Germ-line DNA of 78 acromegalic patients was screened for known genetic variants of PDE11A by direct sequencing or restric...

ea0014p102 | (1) | ECE2007

Cortisol excess, inflammatory markers and echocardiographic alterations in adrenal incidentalomas

Ermetici Federica , Malavazos Alexis , Coman Calin , Morricone Lelio , Corsi Massimiliano , Ambrosi Bruno

An increased cardiovascular risk has been described in patients (pts) with adrenal incidentaloma (AI), similarly to pts with overt Cushing’s syndrome (CS). Some echocardiographic abnormalities and alterations in adipokine secretion involved in insulin resistance, inflammation and atherosclerosis have been reported in pts with CS. In this study the possible correlation between echocardiographic parameters and adipokine levels in pts with AI was evaluated.<p class="abst...

ea0022oc1.5 | Diabetes and obesity | ECE2010

Role of PKA regulatory subunit R2B in murine and human adipocyte differentiation

Ermetici Federica , Peverelli Erika , Mantovani Giovanna , Corbetta Sabrina , Avagliano Laura , Bulfamante Gaetano , Beck-Peccoz Paolo , Spada Anna

PKA regulatory subunit 2B (R2B) is the most expressed in mouse adipose tissue, where it plays an important role in regulating energy balance. We previously demonstrated that R2B is the most abundant R subunit in human adult subcutaneous and visceral adipose tissues. We further showed that R2B expression and PKA activation are reduced in adipose tissues from obese as compared to non-obese subjects. Normal adipose tissue development and increases in fat mass associated with obes...

ea0049oc6.2 | Diabetes therapy and complications | ECE2017

Insulin-mimetic effects of short-term Rapamycin in type 1 diabetic patients prior islet transplantation

Ermetici Federica , Briganti Silvia , Benedini Stefano , Codella Roberto , Maffi Paola , Caldara Rossana , Secchi Antonio , Piemonti Lorenzo , Alejandro Rodolfo , Ricordi Camillo , Luzi Livio

It has been suggested that the selective m-TOR inhibitor, Rapamycin, has been improved the success pancreatic islet allotransplantation (ITx) in type 1 diabetic patients (T1DM). Forty-one ITx were studied. Thirteen T1DM in poor glycemic control underwent a 45-days Rapamycin before ITx followed by standard Edmonton Protocol (EP, group 1, Milan), and they were compared to 28 T1DM patients undergoing EP (group 2, Miami). Outcome measures were daily insulin requirement (DIR), HbA1...

ea0037gp.10.09 | Calcium, Vitamin D and Bone | ECE2015

Serum cystatin C levels were correlated with cardiometabolic features and cardiovascular diseases in patients with primary hyperparathyroidism

Verdelli Chiara , Ermetici Federica , Filopanti Marcello , Verga Uberta , Passeri Elena , Dito Giorgia , Malavazos Alexis Elias , Mapelli C , Raggi M E , Corbetta Sabrina

Patients with primary hyperparathyroidism (PHPT) are at risk of chronic kidney disease (CKD). PHPT patients (n=190, 146 females and 44 males, aged 59.7±14.2 years) and non-hypertensive, non-diabetic age- and sex-matched healthy controls were evaluated for serum cystatin C and creatinine. PHPT patients and controls with established CKD were excluded. Serum cystatin C was measured by immunonephelometric assay and calculation of estimated glomerular filtration rate ...

ea0035p766 | Obesity | ECE2014

Vertebral bone marrow fat is increased in obese women: relationship with epicardial fat

Ermetici Federica , Briganti Silvia , Delnevo Alessandra , Cannao Paola , Secchi Francesco , Leo Gianni Di , Bandera Francesco , Dozio Elena , Romanelli Massimiliano Marco Corsi , Sardanelli Francesco , Morricone Lelio , Malavazos Alexis Elias

Introduction: Bone marrow fat is considered a risk factor for osteoporosis and fragility fracture. It is not clear if bone marrow adiposity is increased in obesity and how it relates to other compartments of adipose tissue, in particular visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and epicardial adipose tissue (EAT).Aim: To evaluate bone marrow adiposity in obese as compared with normal weight women.Design: Tw...

ea0022p632 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Modification of epicardial fat thickness in adult GHD patients after short-term replacement therapy with rhGH

Ferrante Emanuele , Giavoli Claudia , Malavazos Alexis , Ermetici Federica , Bergamaschi Silvia , Ronchi Cristina , Coman Calin , Passeri Elena , Corbetta Sabrina , Lania Andrea , Ambrosi Bruno , Spada Anna , Beck-Peccoz Paolo

Adult GH deficiency syndrome is characterized by visceral obesity, dyslipidemia, insulin resistance and is associated with an increased cardiovascular risk. Epicardial adipose tissue, giving its relationship with abdominal visceral adiposity, coronary artery disease, cardiac morphology and function and metabolic syndrome, has been proposed as cardio-metabolic risk indicator. In this study, we evaluated the echocardiographic epicardial fat thickness in 14 patients (8 M and 6 F,...