Searchable abstracts of presentations at key conferences in endocrinology

ea0014p246 | (1) | ECE2007

Hyperactivity of the hypothalamic-pituitary-axis and adrenal hyperandrogenism in polycystic ovary syndrome: a consequence of 5 β-reductase hyperfunction

Gambineri Alessandra , Patton Laura , Forlani Giulia , Munarini Alessandra , Tomassoni Federica , Pagotto Uberto , Pasquali Renato

Among the uncertainties surrounding the etiology of polycystic ovary syndrome (PCOS) the role of increased peripheral cortisol metabolism has become interesting, particularly in relationship to the pathogenesis of adrenal hyperandrogenism. The patways of cortisol metabolism include irreversible inactivation of cortisol by 5α- and 5β-reductase. To evaluate the association of 5α- and 5β-reductase activity with adrenal hyperandrogenism in PCOS, we recruited 90...