Searchable abstracts of presentations at key conferences in endocrinology

ea0084ps2-06-48 | Hypothyroidism Treatment | ETA2022

Pseudomalabsorption of levothyroxine: munchausen’s syndrome, compliance defects or fraud?

Campi Irene , Carrara Silvia , Federici Silvia , Trevisan Matteo , Persani Luca , Fugazzola Laura

Objectives: Factitious disorder imposed on self or MunchausenÂ’s syndrome (MS), is a psychiatric disorder in which physical symptoms are intentionally produced without any practical benefit. Patients with MS represent a diagnostic dilemma as laboratory and clinical results can be inconsistent with the history and physical exam. The aim of this study was to evaluate the role of the levothyroxine overload test to differentiate MS from malabsorption and to treat life-threaten...

ea0073oc4.3 | Oral Communications 4: Reproductive and Developmental Endocrinology | ECE2021

Gender difference in genetic and diagnosis of congenital hypogonadotropic hypogonadism (CHH) in a large cohort from an Endo-ERN referral center

Federici Silvia , Cangiano Biagio , Goggi Giovanni , Persani Luca , Bonomi Marco

Congenital hypogonadotropic hypogonadism (CHH) is a rare condition characterized by impairment of pubertal development, that can be associated with hypo/anosmia (Kallmann Syndrome, KS) or normosmia (nCHH). A genetic basis can be identified in nearly 50% of cases, with increasingly common detection of oligogenicity. CHH has a strong male predominance (MtoF ratio 5–3:1), although sex ratio for CHH in families with autosomal inheritance has been proven to be close to equal....

ea0099ep886 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Physical exercise as a sustainability tool in men affected with metabolic syndrome-related late-onset central hypogonadism: role of endocrine-metabolic and neurovegetative outcomes

Giovanelli Luca , Cangiano Biagio , Federici Silvia , Lucini Daniela , Bonomi Marco

Background: Late-onset central hypogonadism (LOH), whose prevalence is high among dysmetabolic males, impairs quality of life and increases cardiovascular risk. Although lifestyle modification is the first-line therapeutic strategy, it often fails in clinical practice, probably due to socio-cultural, economic and organisational barriers, as well as the lack of effective and sustainable intervention programs.Aim: To delineate sustainable physical exercise...

ea0090p546 | Late-Breaking | ECE2023

Polycythemia vera and feminizing hormone treatment in an individual Assigned Male at Birth (AMAB): a prickly situation

Parazzoli Chiara , Delle Donne Elisa , Federici Silvia , Amer Myriam , Persani Luca , Bonomi Marco , Bonadonna Stefania

Introduction: Feminizing hormone therapy (HT) for male-assigned at birth (AMAB) includes estrogens, often in combination with anti-androgens. Several studies have reported an increased incidence of cardiovascular diseases and venous thromboembolism in AMAB receiving estrogens. Indeed, procoagulant changes induced by estrogen-based HT occur in transwomen as well as in cisgender individuals. Therefore, using estrogen in gender-affirming HT is relatively contraindicated in those ...

ea0070aep807 | Reproductive and Developmental Endocrinology | ECE2020

Genetic background and previous androgenization are associated with reproductive and non-reproductive outcomes of Gonadotropin-mediated pubertal induction in Congenital Hypogonadotropic Hypogonadism (CHH)

Cangiano Biagio , Goggi Giovanni , Federici Silvia , Guizzardi Fabiana , Vezzoli Valeria , Duminuco Paolo , Persani Luca , Bonomi Marco

CHH is a rare disease with a relevant genetic background, and is characterized by a failure to enter (complete forms) or to complete (partial forms) pubertal development. It requires a treatment to allow the completion of puberty, and in male this goal can be achieved either using testosterone replacement therapy or administering gonadotropins (Gn); the latter allows both testicular development and the endogenous testosterone production. There are few studies evaluating the th...

ea0099rc1.3 | Rapid Communications 1: Reproductive and Developmental Endocrinology | ECE2024

Clinical and genetic characterization of a large cohort of patients with premature ovarian failure

Federici Silvia , Messetti Dario , Rossetti Raffaella , Moleri Silvia , Persani Luca , Bonomi Marco

Primary ovarian insufficiency (POI) affects 1% of women before age 40 years, and in 70-90% of cases is defined as idiopathic. Although numerous POI-associated genes have been identified in recent years, the prevalence and pathogenicity of individual rare gene variants is still difficult to establish. The aim of our study was to retrospectively analyze the correlation between genotype and phenotype in patients with idiopathic POI, providing a more detailed characterization of P...

ea0090p270 | Late-Breaking | ECE2023

Monitoring serum estradiol levels in clinical practice: a retrospective study in transgender AMAB subjects

Federici Silvia , Garofalo Chiara , Parazzoli Chiara , Amer Myriam , Delle Donne Elisa , Persani Luca , Bonadonna Stefania , Bonomi Marco

The Standards of Care version 8 (SOC 8) for transgender and gender diverse people suggest maintaining estradiol (E2) levels between 100-200 pg/ml in Assigned Male at Birth (AMAB) subjects who desire a complete feminization during gender affirmation hormone therapy (GAHT). However, data about estrogen dose therapy and corresponding serum concentrations are scarce, especially regarding gel formulations. Our aim was to retrospectively compare E2 serum levels in AMAB patients unde...

ea0081rc12.7 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Pubertal induction in girls with hypogonadism: insight into estrogen replacement therapy outcomes and optimization of progesterone introduction

Rodari Giulia , Federici Silvia , Cattoni Alessandro , Todisco Tommaso , Ubertini Graziamaria , Giacchetti Federico , Profka Eriselda , Dall'Antonia Alberta , Cangiano Biagio , Arosio Maura , Bonomi Marco , Cappa Marco , Giavoli Claudia

Background: Pubertal induction in girls with hypogonadism through estrogen replacement therapy (ERT) aims at mimicking physiological puberty. To date, the best induction regimen is still to be established.Aims: By setting up a multicentre clinical registry, we analysed longitudinal data on pubertal induction in girls with hypogonadotropic hypogonadism or premature ovarian insufficiency (congenital, acquired, isolated or associated with multiple pituitary...

ea0090p736 | Reproductive and Developmental Endocrinology | ECE2023

The Impact of Covid-19 Lockdown on Pubertal Onset in A Second Level Center

Goggi Giovanni , Moro Mirella , Chila Alessandro , Fatti Letizia , Cangiano Biagio , Federici SIlvia , Galazzi Elena , Carbone Erika , Soranna Davide , Vezzoli Valeria , Persani Luca , Bonomi Marco

Background: As of December 2019, the COVID-19 pandemic has spread rapidly, therefore Governments from all over the world promoted a strategy of social confinement through a general lockdown in order to contain it. During the months following its introduction, many studies reported a significant increase in the incidence of idiopathic central precocious puberty (CPP) throughout several countries, especially in girls.Purpose: The aim of our study was to co...