Searchable abstracts of presentations at key conferences in endocrinology

ea0011s88 | Contrasting practices in European endocrinology | ECE2006

Diagnosis of hypercortisolism

Feelders RA

The diagnosis and differential diagnosis of hypercortisolism can be a major clinical challenge and involves several stages. In each stage different approaches are currently followed. There are, however, some general principles. In brief, after critical judgement of clinical features, the first step is to assess whether endogenous hypercortisolism is present. First-line tests to screen for hypercortisolism include measurement of 24 h urinary cortisol excretion, cortisol diurnal...

ea0056p735 | Endocrine tumours and neoplasia | ECE2018

Utility of a 3D spheroid cell culture system in neuroendocrine tumors

Herrera-Martinez AD , van Dungen ESR , Dogan F , van Koetsveld1 PM , Castano JP , Feelders RA , Hofland LJ

In vitro 3D cell culture systems seem to appropriately reproduce the tumor cell microenvironment, including nutrients-oxygen conditions and cell-cell interactions. These models may better mimic in vivo tumor conditions and more accurately reproduce drug treatments effects. Since most in vitro studies in neuroendocrine tumors (NETs) are performed in 2D culture systems (monolayer), we aimed to compare the monolayer system with a 3D spheroid cell cultur...

ea0056gp45 | Adrenal medulla and NETs | ECE2018

The 10 Hounsfield Units cut-off value on unenhanced CT imaging is highly sensitive to diagnose pheochromocytoma: a multicenter study

Buitenwerf E , Korteweg T , Haag MSC , Feelders RA , Timmers HJLM , Canu L , Haak HR , Bisschop PHLT , Eekhoff EMW , Corssmit EPM , Dullaart RPF , Links TP , Kerstens MN

Introduction: A substantial proportion of pheochromocytomas (PCC) are detected during the work-up of an adrenal incidentaloma. Recently it has been suggested that in case of an adrenal incidentaloma with an unenhanced attenuation value <10 Hounsfield Units (HU) on CT imaging biochemical testing to rule out PCC is unnecessary. We aimed to determine the sensitivity of the 10 HU cut-off value to detect pheochromocytoma.Methods: Retrospective multicenter...

ea0056oc7.5 | Genomic and clinical aspects of endocrine tumours | ECE2018

Randomized trial comparing phenoxybenzamine and doxazosine for preoperative treatment of patients with a pheochromocytoma (PRESCRIPT)

Buitenwerf E , Osinga TE , Timmers HJLM , Lenders JWM , Feelders RA , Eekhoff EMW , Haak HR , Corssmit EPM , Bisschop PHLT , Valk GD , GrooteVeldman R , Dullaart RPF , Links TP , Voogd MF , Wietasch JKG , Kerstens MN

Background: Administration of α-adrenergic receptor antagonists is recommended before resection of a pheochromocytoma (PCC) in order to prevent perioperative cardiovascular complications. For this purpose either phenoxybenzamine (PXB) or doxazosin (DOX) is commonly prescribed. We conducted the first randomized controlled trial comparing the efficacy of PXB and DOX in controlling perioperative hemodynamics in patients undergoing PCC resection (