ea0011p311 | Diabetes, metabolism and cardiovascular | ECE2006
Heutling D
, Sayk F
, Dodt C
, Fehm HL
, Frank T
, Hinney A
, Hebebrand J
, Lehnert H
Activation of the melanocortin-4 receptor (MC4R) leads to a decrease of appetite and an elevation of sympathetic nerve activity (SNA). The sympathoexcitatory property of leptin is mediated by the melanocortin system and a functional MC4R is a prerequisite for the development of hypertension associated with obesity in animal model. To test the hypothesis that functional mutations of the MC4R lead to a diminished SNA in humans, ten carriers of MC4R mutations and a control group ...