Searchable abstracts of presentations at key conferences in endocrinology

ea0081rc10.5 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

GLP-1RAs and glucagon can reshape adipose differentiation in vitro by activating the “browning process”

Cantini Giulia , Trabucco Martina , Fei Laura , Propato Arianna , Guasti Daniele , Quartararo Giovanni , Maggi Mario , Mannucci Edoardo , Luconi Michaela

Obesity is associated with increased and dysfunctional white adipose tissue (WAT). Pharmacological approaches of obesity are still far from obtaining a stable weight loss. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been proposed as anti-obesity drugs due to their effects on weight loss. Furthermore, dual agonists engaging both GLP-1 and glucagon are currently under investigation for their marked effects on weight loss, although their mechanisms of action is stil...

ea0073pep11.1 | Presented ePosters 11: Adrenal and Cardiovascular Endocrinology | ECE2021

Fascin-1, a novel-circulating marker for the prognosis of the metastatic adrenocortical carcinoma

Cantini Giulia , Canu Letizia , De Filpo Giuseppina , Ercolino Tonino , Fei Laura , Nesi Gabriella , Maggi Mario , Mannelli Massimo , Luconi Michaela

Fascin-1(FSCN1) is an actin-bundling protein expressed in several solid carcinomas and often associated to an invasive and aggressive phenotype as it is involved in cytoskeleton rearrangement and filopodia formation. Adrenocortical carcinoma (ACC) is a rare endocrine malignancy characterized by a poor prognosis, particularly when metastatic at diagnosis. Complete surgical resection of the tumor mass is the main therapy for ACC patients in addition to the adjuvant administratio...

ea0073pep11.3 | Presented ePosters 11: Adrenal and Cardiovascular Endocrinology | ECE2021

Identification of carbonic anhydrases III and IX in the adipose microenvironment of adrenocortical carcinoma

Fei Laura , Cantini Giulia , Nocentini Alessio , Canu Letizia , Nardini Patrizia , De Filpo Giuseppina , Ercolino Tonino , Nesi Gabriella , Maggi Mario , Bani Daniele , Mannelli Massimo , Supuran Claudiu T , Luconi Michaela

The adipose tissue (AT) is an important endocrine organ. Upon energy imbalance, the adipose cells become dysfunctional, supporting the development of metabolic pathologies and tumours. The adipose cell is among the main actor of the tumor microenvironment, and is able to establish a crosstalk with the cancer cell resulting in a reciprocal reprogramming. Adrenocortical carcinoma (ACC) is a rare endocrine malignancy affecting the adrenal cortex. In the most aggressive forms, can...