Searchable abstracts of presentations at key conferences in endocrinology

ea0063p611 | Diabetes, Obesity and Metabolism 2 | ECE2019

Prenatal metformin treatment in obese rats: Evaluation of liver norepinephrine and lipogenic enzymes in offspring

Valero Viviana , Fernandois Daniela , Alvarez Daniela , Cruz Gonzalo

Maternal obesity during pregnancy is associated with several metabolic impairments in offspring, some of them evidenced from early infancy. Some reports have demonstrated that offspring of obese rats, whose obesity was induced by high fat diet consumption, have an increase sympathetic tone and increased norepinephrine (NE) content in kidney, liver and ovary. We recently reported that maternal administration of metformin prevents the increase in ovarian NE in offspring when the...

ea0037gp.07.02 | Reproduction: Female and other | ECE2015

Kisspeptin increased during reproductive ageing and is regulated by sympathetic nerve system

Fernandois Daniela , Marquez Ruth , Lara Hernan , Paredes Alfonso

Kisspeptin is found in the ovary of different species including human and rat. We have recently described, through in vitro studies, that kisspeptin is under the control of sympathetic innervation of the ovary. Considering that ovarian activity of sympathetic nerves increases with ageing, it is possible that the ovarian kisspeptin also increases during this period. As a role of kisspeptin in folliculogenesis has been postulated, this increase in kisspeptin could parti...

ea0041gp147 | Paediatric Endocrinology & Development | ECE2016

Prenatal metformin treatment prevents estradiol increase and partially improves ovarian function in offspring of obese mothers

Alvarez Daniela , Olguin Sofia , Ceballo Karina , Martinez Jonathan , Cerda Tania , Fernandois Daniela , Cruz Gonzalo

Obesity epidemic is one of the major concerns in the world. Worryingly, a high percentage of pregnant women have obesity, which could imply several consequences. Maternal obesity leads to different abnormalities in pregnancy and delivery. In addition, recent studies show that the offspring of obese mothers has an increased probability to suffer cardiovascular, metabolic and reproductive diseases. We have previously demonstrated that exposure to a high fat diet is related to ob...

ea0037ep157 | Reproduction, endocrine disruptors and signalling | ECE2015

Maternal obesity in pregnant rats is associated to increased levels of oestradiol during early postnatal life and altered ovarian follicular development in the offspring

Reyes Aldo , Ramirez Luisa , Ambrosetti Valery , Guerra Marcelo , Alvarez Daniela , Olguin Sofia , Fernandois Daniela , Sotomayor-Zarate Ramon , Cruz Gonzalo

Obesity during gestation has been related to predisposition to endocrine and metabolic diseases in the offspring. Regarding reproductive effects, an increase in BMI in pregnant mothers is associated with precocious puberty in their offspring. This has been replicated in animal models of high fat diet (HFD) administration to mothers. Also, gestational obesity has been associated to higher susceptibility to developing breast cancer in the offspring. As both precocious puberty an...

ea0056oc2.4 | Look who is controlling your gonads! | ECE2018

Novel role of central ceramide signaling in mediating obesity-induced precocious puberty

Heras Violeta , Castellano Juan Manuel , Fernandois Daniela , Velasco Inmaculada , Roa Juan , Vazquez Maria J. , Ruiz-Pino Francisco , Pineda Rafael , Torres Encarnacion , Avendano Maria Soledad , Gaytan Francisco , Pinilla Leonor , Lopez Miguel , Casals Nuria , Tena-Sempere Manuel

Childhood obesity has become a major health problem, which is coupled to different adverse outcomes and diseases. The escalating prevalence of child obesity parallels that of alterations in pubertal timing, also linked to higher disease burden later on life. Yet, the mechanisms underlying for this association remain unfolded. Ceramides, ubiquitous signaling molecules involved in numerous biological processes, have emerged as mediators of metabolic disorders and transmitters fo...