Endocrine Abstracts

Introduction: Growth Hormone deficiency (GHD) is frequent in patients with human immunodeficiency virus 1 (HIV-1), undergoing highly active antiretroviral therapy. GHD seems to depend on HIV-related lipodystrophy and to be less frequent in women.Aim of the study: To investigate the association of gender, body composition and GH/IGF1 axis, and to clarify whether GHD in HIV-infected patients is functional or a clinical entity.Methods...

Background: SUB:Pituitary – Clinical (Generously supported by IPSEN)GH response to GHRH+Arg is impaired in HIV-infected men and women, compared to gender matched controls. Moreover, reduced GH secretion seems to occur more frequently in HIV-infected males than females.Methods: To determine gender effects on GH secretion in HIV-infected patients with lipodystrophy, we compared GH/IGF1 status and body composition in 103 males and 97 females. ...

Background: GH–IGF1 status is important for bone health. Acromegaly affects bone status, but less is known on the role of treatments for acromegaly on bone mineral density (BMD). Pegvisomant (Peg) is effective in treating acromegaly by reducing IGF1. As serum GH is not influenced by Peg, it is not known if residual, direct GH effects on bone (not IGF1 mediated) are preserved during treatment.Methods: To evaluate the effects of Peg on BMD, we compare...