Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep64 | Adrenal and Cardiovascular Endocrinology | ECE2023

Cushing’s Syndrome due Primary bilateral macronodular adrenal hyperplasia–a case series from a tertiary hospital

Goncalves Juliana , Ferreira Helena Urbano , Pedro Jorge , Carvalho Davide , Freitas Paula

Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of CushingÂ’s syndrome (CS). It is a highly heterogeneous disease with multiple adrenal macronodules and variable levels of cortisol excess. The pathogenesis is complex and different mechanisms such as aberrant hormone receptors, local production of ACTH in adrenal tissues and genetic mutations have been identified. The approach is not well established. Nine patients with PBMAH who are currently fol...

ea0090ep717 | Pituitary and Neuroendocrinology | ECE2023

Bilateral petrosal sinus sampling – a 15-year experience from a tertiary hospital

Ferreira Helena Urbano , Goncalves Juliana , Belo Sandra , Alves Goncalo , Silva Maria Luis , Carvalho Davide , Freitas Paula

Introduction: In patients with ACTH-dependent Cushing Syndrome, differentiating between pituitary and ectopic sources can be challenging. Noninvasive testing can be performed, but bilateral inferior petrosal sinus sampling (BIPSS) remains the gold standard. In the last years however, novel imaging modalities, namely 3T-MRI with 3-dimensional spoiled gradient-echo sequence and 68Ga-tagged CRH combined with positron emission tomography, have been proposed as alternatives.<p ...

ea0090ep315 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Levothyroxine dosing following bariatric surgery – A 4-year follow up

Ribeiro Sara , Lima Bruno A , Goncalves Juliana , Moreno Telma , Ferreira Helena Urbano , Pedro Jorge , Varela Ana , Carvalho Davide , Freitas Paula

Introduction: The anatomical and physiological changes induced by bariatric surgery (BS) can significantly impact the absorption and pharmacokinetics of orally administered medication. In particular, levothyroxine (LT4) dosage, given its dependence on patientÂ’s weight and gastric pH for optimal absorption, is expected to change following BS. However, the literature is not unanimous and there is a void of longer-term studies. We aimed to compare LT4 dosage 4 years followin...

ea0090ep286 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Prediabetes remission after bariatric surgery: A 4-years follow-up study

Borges-Canha Marta , Neves Joao Sergio , Silva Maria , Mendonca Fernando , Moreno Telma , Ribeiro Sara , Vale Catarina , Goncalves Juliana , Ferreira Helena Urbano , Santos Sara , Calheiros Raquel , Meira Ines , Menino Joao , Guerreiro Vanessa , Pedro Jorge , Varela Ana , Souto Selma , Lima da Costa Eduardo , Freitas Paula , Carvalho Davide , Group CRIO

Background: Bariatric surgery leads to weight loss and to cardiometabolic risk improvement. Although prediabetes remission after bariatric surgery is biologically plausible, data on this topic is scarce.Aim: We aimed to access pre-diabetes remission rate and clinical predictors of remission in a 4 year follow up period.Methods: Observational longitudinal study including patients with morbid obesity and prediabetes submitted to bari...