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ea0056ep115 | Pituitary and Neuroendocrinology | ECE2018

Macroprolactinemia diagnosed in a patient evaluated for primary infertility

Nogueira Claudia , Cunha Filipe , Ferreira Ivan , Mesquita Joana

Introduction: Hyperprolactinemia is associated with suppression of the hypothalamic-pituitary-gonadal axis and it’s a frequent cause of infertility, occurring in about 30–40% of infertile women. The bioactive fraction of prolactin is a 23-kDa monomer. However, there are other isoforms with reduced or absent bioactivity, such as macroprolactin, which can be detected by the precipitation reaction by polyethylene glycol. Macroprolactinemia should be suspected in the pre...