Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep129 | Clinical case reports - Pituitary/Adrenal | ECE2017

Aldosterone-producing adrenocortical carcinoma and alteration of secretion pattern on recurrence: a case report

Ferreira Joana Lima , Marques Ana Paula , Sottomayor Carlos , Valente Vitor

Introduction: Adrenocortical carcinoma (ACC) is a rare neoplasm with a variable but overall poor prognosis. The presentation is heterogeneous usually with mass effect and less often with evidence of hormonal secretion. About half of cases the tumors are hormonally active most commonly with cortisol secretion followed by sexual hormones production, being rare the aldosterone secretion.Case report: A 41-year-old male presented with hypertensive crisis and ...

ea0049ep337 | Clinical case reports - Thyroid/Others | ECE2017

Symptomatic bisphosphonate-induced hypocalcaemia after severe idiopathic hypercalcaemia

Ferreira Joana Lima , Tavares Teresa , Moco Rui , Melo Pedro

Introduction: Bisphosphonates, generally considered as safe drugs, are potent inhibitors of bone calcium outflow used to treat osteoporosis and hypercalcemia associated with malignancy. Bisphosphonate-induced hypocalcaemia is an increasingly reported complication, but it has not yet been a subject of comprehensive research.Case report: A 65-year-old woman had a history of Crohn’s disease and ankylosing spondylitis medicated with prednisolone and eta...

ea0081p611 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Influence of dopamine receptor d2 and dopamine transporter polymorphisms in angiopathy in patients with type 2 diabetes mellitus

Neves Marta , Santos Ana Carolina , Ferreira Joana , Raposo Joao F. , Valente Ana , Bicho Manuel

Introduction and Aim: Dopamine receptor D2 (DRD2) polymorphism (rs1800497) appears to be associated with increased susceptibility to the development of type 2 diabetes mellitus (T2DM). The dopamine transporter (DAT) determines dopamine signalling, responsible for the reuptake of its active form from the synapse. Polymorphism in the DAT gene (rs2836317) can increase dopamine reuptake in the synaptic cleft. However, its association with T2DM is still controversial.<p class="...

ea0090p40 | Calcium and Bone | ECE2023

Polymorphisms in genes related to iron metabolism and DNA methylation and their interaction with estradiol in susceptibility to osteoporosis in postmenopausal women

Aguiar Laura , Ferreira Joana , Paula Barbosa Ana , Rui Mascarenhas Mario , Faustino Paula , Inacio Angela , Bicho Manuel

Introduction: Osteoporosis is a multifactorial disease characterized by reduced bone mass and increased risk of fragility fractures. Menopause predisposes women to osteoporosis due to declining estrogen levels. Iron is known to play a relevant role in the development of osteoporosis since iron suppresses osteoblast formation and may also stimulate osteoclast resorption of bone. Also, homocysteine is a known risk factor for osteoporotic fractures and is related to DNA methylati...

ea0090ep83 | Adrenal and Cardiovascular Endocrinology | ECE2023

Primary adrenal insufficiency in the context of small-cell neuroendocrine prostate cancer

de Brito Marques Francisca , Magalhaes Helena , Ferreira Joana Lima , de Carvalho Francisco Simoes , Marques Ana Paula

Introduction: The small-cell neuroendocrine prostate carcinoma (SCPC) is rare, highly aggressive and usually transforms from prostate adenocarcinoma (PAC) after androgen deprivation therapy (ADT).Case Report: A 66-year-old man had a three-year history of high-grade PAC with high burden disease (abdominal lymph node and bone metastasis) at presentation (09/2019). On the initial staging evaluation, the CT scan documented a 20 mm left adrenal nodule compati...

ea0090ep188 | Calcium and Bone | ECE2023

22q11.2 deletion syndrome diagnosed in the context of a seizure in adulthood

de Brito Marques Francisca , Simoes de Carvalho Francisco , Ferreira Joana Lima

Introduction: The 22q11.2 deletion syndrome or DiGeorge syndrome (DGS) is rare and the diagnosis in adults is uncommon. The phenotype is highly heterogeneous and of variable severity, including hypoparathyroidism and epilepsy.Case Report: A 26-year-old man was admitted in the emergency room for inaugural tonic-clonic seizure. He had history of cognitive impairment and learning difficulties. Neurologic examination, brain CT and basic analysis were irrelev...

ea0090ep1061 | Thyroid | ECE2023

Prolonged Survival in Follicular Thyroid Cancer with Bone Metastasis

de Brito Marques Francisca , Simoes de Carvalho Francisco , Lima Ferreira Joana , Paula Marques Ana

Introduction: Follicular thyroid cancer (FTC) accounts for 12% of differentiated thyroid cancers (DTC). It is frequently complicated by bone metastasis (BM), which impact quality of life (QOL) and decreases the 10-year survival rate to 13-21%.Case Report: A 53-year-old woman followed at the Pain Clinic for over 10 years for lower back pain, had been operated three years before due to lumbar disc herniation. Pain relapsed one year after surgery and was re...

ea0063p1028 | Interdisciplinary Endocrinology 2 | ECE2019

Impact of hormonal factors in the genesis of sarcopenia

Mascarenhas Mario Rui , Barbosa Ana Paula , Fortes Indira , Ferreira Joana , Bicho Manuel

The European Working Group on Sarcopenia in Older People (EWGSOP2) defined in 2018 ‘sarcopenia as muscle disease (muscle failure), with low muscle strength overtaking the role of low muscle mass as a principal determinant’; sarcopenia increases risk of falls and fractures, impairs ability to perform activities of daily living, leads to mobility disorders and low quality of life and death. The diagnosis is confirmed by low muscle quantity or quality. The muscle quanti...

ea0049ep1362 | Thyroid (non-cancer) | ECE2017

Levothyroxine absorption test in the management of a patient with persistent hypothyroidism

Monteiro Joana , Ferreira Marta , Pires Miguel , Vieira Alexandra , Guelho Daniela , Pereira Teresa , Pinhal Fernanda , Fernandes Celio

Nonadherence to levothyroxine therapy is one cause of persistent hypothyroidism. To distinguish nonadherence from malabsorption, a levothyroxine absorption test (LAT) is sometimes required. The authors report a case of a 60-year-old female patient suffering from hypothyroidism resistant to oral levothyroxine (LT4) substitution after radioiodine therapy for Graves’ disease. Despite the continuous increases of LT4, over 10 years, to a maximum of 1 mg/d...

ea0081p550 | Calcium and Bone | ECE2022

Biochemical parameters in metabolic bone disease of obese patients

Binda Pereira Raquel , Santos Ana Carolina , Ferreira Joana , Mascarenhas Mario Rui , De Quinhones Levy Pilar , Barbosa Paula , Bicho Manuel

Introduction: Obesity is a pathological condition characterized by a low-grade systemic inflammatory state that predisposes to the onset of some diseases, such as hypertension, diabetes, and hyperlipidemia. Also, obesity can impact bone metabolism, but its effects are controversial.Aims: This observational study aimed to evaluate and correlate the bone mass with the lipidic profile, adipocytokines, glucose metabolism, hepatic function and purine metaboli...