Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep62 | Adrenal and Cardiovascular Endocrinology | ECE2022

Synchronous adrenal gland masses in a patient: clinical case

Ferreira Mafalda Martins , Lavrador Mariana , Araujo Catia , Guiomar Joana Reis , Moreno Carolina , Oliveira Patricia , Paiva Isabel

We describe the case of a 69-year-old woman with bilateral adrenal incidentalomas identified in CT-scan: on the right, a 57 mm heterogeneous mass with <10 Hounsfield units(HU) with absolute washout of 16%; on the left a 13 mm mass with 35UH, intense contrast enhancement but washout of 66%. She had a recent onset of diabetes, hypertension, androgenic alopecia and facial hair. The systolic blood pressure remained persistently >160 mmHg despite receiving four antihyperten...

ea0081ep63 | Adrenal and Cardiovascular Endocrinology | ECE2022

Malignant pheochromocytoma with bone, pulmonary and brain metastases

Araujo Catia , Ferreira Mafalda Martins , Lavrador Mariana , Moreno Carolina , Oliveira Patricia , Baptista Carla , Paiva Isabel

Introduction: Pheochromocytomas are rare neuroendocrine tumors whose malignancy is defined by the presence of metastases that may appear several years later. The appropriate follow-up time remains uncertain.Clinical Case: We present the case of a woman with a history of pheochromocytoma who underwent complete resection at 48 years old. The genetic evaluation was negative for mutations on RET, VHL, SDHB or SDHD genes. At 66 years old, a thoracic vertebral...

ea0081ep165 | Calcium and Bone | ECE2022

Reduced bone mineral density in primary adrenal insufficiency: consequences of long-term treatment

Araujo Barbara Filipa , Lavrador Mariana , Araujo Catia , Ferreira Mafalda , Barros Luisa , Paiva Sandra , Paiva Isabel

Introduction: The effects of long-term replacement therapy of primary adrenal insufficiency (PAI) are still a matter of debate. Glucocorticoid (GC) replacement regimens do not completely mimic the endogenous hormonal production and their monitoring is sometimes difficult. Therefore, some patients are exposed to mild GC excess with potential complications, such as hypertension, diabetes, and skeletal fragility. Data on bone mineral density (BMD) in PAI is still scarce and contr...

ea0081ep171 | Calcium and Bone | ECE2022

A sporadic case of pseudohypoparathyroidism type Ib and fahr’s syndrome

Araujo Catia , Ferreira Mafalda Martins , Araujo Barbara Filipa , Lavrador Mariana , Baptista Carla , Bastos Margarida , Paiva Isabel

Introduction: Pseudohypoparathyroidism is a heterogeneous disease characterized by hypocalcemia, hyperphosphatemia and parathyroid hormone resistance. The distinct pseudohypoparathyroidism types are distinguished by physical features, the coexistence of other hormone resistances and genetic defects. Pseudohypoparathyroidism type Ib is more often associated with sporadic cases, unlike others types.Clinical Case: Male, born in France, diagnosed with pseudo...

ea0081ep881 | Reproductive and Developmental Endocrinology | ECE2022

Noonan Syndrome, Dandy-Walker variant and delayed puberty- a rare association

Lavrador Mariana , Fadiga Lu cia , Ferreira Mafalda Martins , Barros Lui sa , Paiva Isabel

Introduction: The Dandy-Walker complex (DW) comprises a rare intracranial malformation of the posterior fossa and multiple organ anomalies. The association with endocrine pathology is rare - described in isolated cases (Kallman syndrome, primary hypothyroidism (PH) and central precocious puberty). Noonan syndrome (NS) is a genetic disease usually diagnosed at birth, with variable phenotype. Most cases have AD transmission, with the PTPN11 gene mutation responsible for 50%....

ea0090oc2.3 | Oral Communications 2: Thyroid | ECE2023

The variable clinical spectrum of Thyroid Hormone Resistance Syndrome type β: two different presentations of the same disease

Martins Ferreira Mafalda , Lopes Sofia , Araujo Catia , Oliveira Patricia , Moreno Carolina , Paiva Isabel

Thyroid hormone resistance syndrome(THRS) occurs in 1:40000 live births and can be diagnosed after a period of enigmatic changes in thyroid hormones(TH). Patients may be clinically euthyroid, have clinical hypo or hyperthyroidism. Mostly, it is an autosomal dominant disease due to germline mutations in THR╬▓-gene(exons 7-10). Resistance to peripheral action of TH leads to absence of TSH suppression (which can be normal/elevated) despite elevated fT4 and fT3.<p class="a...

ea0090p296 | Adrenal and Cardiovascular Endocrinology | ECE2023

Cardiometabolic and Kidney Biomarker Effects of Gender-affirming Hormone Therapy in Transgender Males

Filipa Araujo Barbara , Lopes Sofia , Ferreira Mafalda , Ruas Luisa , Paiva Sandra , Paiva Isabel

Introduction: Testosterone-based gender-affirming hormone therapy (GAHT) may have negative consequences on cardiovascular risk, with reported increased blood pressure, decreased HDL-cholesterol, and weight gain. Still, data on cardiometabolic changes in transgender men on GAHT remain controversial. Testosterone-based GAHT also modifies body composition and lean muscle mass, but the degree to which affects serum creatinine and other measures of kidney function is still not clea...

ea0090p692 | Pituitary and Neuroendocrinology | ECE2023

Characterisation of the clinical and biologic behaviour of acromegaly caused by pluri-hormonal tumours in a cohort of 75 patients

Martins Ferreira Mafalda , Carreira Ana , Cardoso Luis , Oliveira Patricia , Melo Miguel , Paiva Isabel

Introduction: The clinical and biochemical spectrum of pituitary acromegaly is wide and variable. There are pure somatotroph tumors(ST), immunohistochemically positive only for GH, and pluri-hormonal(PL), also positive for other hormones, and they appear to have different presentations and responses to treatment.Aims: To compare the clinical presentation, imaging characteristics and response to treatment of acromegalic patients according to the pituitary...

ea0090p174 | Reproductive and Developmental Endocrinology | ECE2023

Congenital Adrenal Hyperplasia – When does Gender Identity Begin?

Lopes Sofia , Ferreira Mafalda , Araujo Barbara , Ruas Luisa , Paiva Sandra , Oliveira Patricia , Paiva Isabel

Introduction: Congenital adrenal hyperplasia (CAH) is a genetic condition which impairs enzymatic steroidogenesis of the adrenal cortex, leading to excessive androgen production. CAH phenotype is heterogeneous. In the mildest forms, it can present with hirsutism, acne and menstrual irregularities. Problems related to gender identification arise in about 5% of people with CAH with a 46,XX karyotype.Objective: We present the case of a young female-to-male ...

ea0090p730 | Reproductive and Developmental Endocrinology | ECE2023

Influence of Obesity on Medically Assisted Reproduction Techniques

Araujo Catia , Baptista Carla , Paiva Isabel , Cortesao Paulo , Martins Ferreira Mafalda

Introduction: Evidence has suggested a relationship between female obesity and the outcomes of medically assisted reproduction techniques (MRT); however, the evidence regarding male obesity is still scarce and discordant. Aim: Evaluate the influence of female and male obesity on the results of MRT.Materials and methods: Retrospective analysis of 2159 couples, with and without obesity, submitted to the first treatment of medically a...