Searchable abstracts of presentations at key conferences in endocrinology

ea0090p296 | Adrenal and Cardiovascular Endocrinology | ECE2023

Cardiometabolic and Kidney Biomarker Effects of Gender-affirming Hormone Therapy in Transgender Males

Filipa Araujo Barbara , Lopes Sofia , Ferreira Mafalda , Ruas Luisa , Paiva Sandra , Paiva Isabel

Introduction: Testosterone-based gender-affirming hormone therapy (GAHT) may have negative consequences on cardiovascular risk, with reported increased blood pressure, decreased HDL-cholesterol, and weight gain. Still, data on cardiometabolic changes in transgender men on GAHT remain controversial. Testosterone-based GAHT also modifies body composition and lean muscle mass, but the degree to which affects serum creatinine and other measures of kidney function is still not clea...

ea0090p174 | Reproductive and Developmental Endocrinology | ECE2023

Congenital Adrenal Hyperplasia – When does Gender Identity Begin?

Lopes Sofia , Ferreira Mafalda , Araujo Barbara , Ruas Luisa , Paiva Sandra , Oliveira Patricia , Paiva Isabel

Introduction: Congenital adrenal hyperplasia (CAH) is a genetic condition which impairs enzymatic steroidogenesis of the adrenal cortex, leading to excessive androgen production. CAH phenotype is heterogeneous. In the mildest forms, it can present with hirsutism, acne and menstrual irregularities. Problems related to gender identification arise in about 5% of people with CAH with a 46,XX karyotype.Objective: We present the case of a young female-to-male ...

ea0090ep926 | Reproductive and Developmental Endocrinology | ECE2023

Growth hormone treatment in SGA children leads to worsening of insulin resistance parameters without beneficial effects on lipid profile – a 3-year retrospective study

Silva Maria , Sergio Neves Joao , Costa Carla , Santos Silva Rita , Ferreira Sofia , Carvalho Davide , Castro-Correia Cintia

Background: Children who were born small for gestational age (SGA) and who do not have adequate catch-up growth until 4 years old have indication for treatment with recombinant human growth hormone (rhGH). The metabolic consequences of this treatment are relatively unknown. Objective: To evaluate the effect of rhGH treatment on insulin sensitivity and lipid profile.Materials and methods: A retrospective observational study of child...

ea0073ep178 | Reproductive and Developmental Endocrinology | ECE2021

Precocious puberty: two siblings, two diagnosis

Maria João Ferreira , Moita Rita , Ferreira Sofia , Costa Carla , Santos Silva Rita , Cíntia Castro-Correia

8-year-old girl is referred to a Pediatric Endocrinologist for the appearance of thelarche, first noted at 6.5 years. She had a relevant clinical history of a neonatal meningitis, requiring prolonged hospitalization and the need for ventriculoperitoneal shunt. On physical examination, she had breast development and dark, coarse pubic hair compatible with Tanner stage 3. She weighed 32.3 kg (percentile – Pc- 75–90), her height was 128 cm (Pc 50) and her annual growth ...

ea0073aep69 | Adrenal and Cardiovascular Endocrinology | ECE2021

Quality of life in children diagnosed with non-classic congenital adrenal hyperplasia

Maria João Ferreira , Moita Rita , Borges-Canha Marta , Silva Rita Santos , Ferreira Sofia , Costa Carla , Carvalho Davide , Cíntia Castro-Correia

IntroductionNon-classical congenital adrenal hyperplasia (NC-CAH) is a chronic disease characterized by excessive androgen production. Affected children may have their quality of life negatively affected by the awareness of a medical condition, symptoms of hyperandrogenism and the burden of daily medication administration. Pediatric Quality of Life Inventory 4.0 (PedsQL) is a validated tool to assess health-related QoL (HRQoL).Meth...