Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep569 | Endocrine-Related Cancer | ECE2022

Novel pathogenetic mutation of MEN1 gene causing hyperparathyroidism, pancreatic glucagonoma, adrenal adenoma, and collagenomas

Pitino Rosa , Vimercati Davide , Pizzolitto Francesca , Mollero Edoardo Luigi Maria , Daffara Tommaso , Ferrero Alice , Boldorini Renzo , Caputo Marina , Prodam Flavia

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary autosomal dominant tumor syndrome caused by inactivating mutations of the tumor suppressor gene MEN1 which encodes the protein menin. It is characterized by the occurrence of tumors involving two or more endocrine glands, primarily parathyroid, entero-pancreatic, and anterior pituitary, as well as non-endocrine neoplasms. Glucagonomas occur in fewer than 3% of patients with MEN1, causing hyper...

ea0073pep12.6 | Presented ePosters 12: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Serum leptin and urine cortisol to cortisone ratio are correlated in familiar partial lipodystrophy type I (Kobberling Syndrome)

Daffara Tommaso , Mancioppi Valentina , Caputo Marina , Leone Ilaria , Ferrero Alice , Pelosini Caterina , Santini Ferruccio , Aimaretti Gianluca , Ceccarini Giovanni , Prodam Flavia

BackgroundIn lipodystrophy (LD) adipose tissue function is impaired, leading to a severe metabolic syndrome. Familiar Partial LD (FPLD) type I (Kobberling Syndrome) overlaps with CushingÂ’s syndrome phenotype. The latter and the metabolic impairment observed in FPLD1 may suggest a crosstalk between the HPA axis, assuming that leptin sensitivity is preserved in this context. We aimed to evaluate if leptin levels are associated with glucocorticoid acti...

ea0081p673 | Pituitary and Neuroendocrinology | ECE2022

Transition in endocrinology: predictors of drop-out in a heterogeneous population during long-term follow-up

Romanisio Martina , Brasili Sara , Daffara Tommaso , Ferrero Alice , Vimercati Davide , Pizzolitto Francesca , Pitino Rosa , Luigi Maria Mollero Edoardo , Zavattaro Marco , Bellone Simonetta , Caputo Marina , Aimaretti Gianluca , Prodam Flavia

Aim: To evaluate: 1) clinical and epidemiological characteristics of outpatients transitioned from Pediatrics Endocrine (PED) to Adult Endocrine Department (AED) in a tertiary Centre; 2) transition process characteristics, and predictive factors of drop-out.Patients and methods: Demographic, clinical, and transition features of 170 consecutive patients with paediatric onset of chronic endocrine or metabolic disease (excluded type 1 diabetes) who transiti...

ea0081ep90 | Adrenal and Cardiovascular Endocrinology | ECE2022

Tumor enlargement in adrenal incidentaloma is related to glaucoma and statin treatment: are there two new prognostic features?

Ferrero Alice , Daffara Tommaso , Mele Chiara , Zavattaro Marco , Romanisio Martina , Cavigiolo Beatrice , Costelli Samuele , Caputo Marina , Marzullo Paolo , Prodam Flavia , Aimaretti Gianluca

Aim: The uncertainty on the management of small adrenal incidentalomas (AIs) in guidelines still represents a challenge in real clinical practice. The aim of the study was to identify risk factors for morphological or functional changes during follow-up by using clinical, radiological, and pathological features.Methods: We retrospectively evaluated demographic (gender and age at diagnosis), clinical (weight, height, body mass index, smoking habit, comorb...

ea0090p11 | Adrenal and Cardiovascular Endocrinology | ECE2023

Diagnostic accuracy of 18F-FDG PET/TC for the characterization of adrenal lesions in a heterogeneous population

Romanisio Martina , Daffara Tommaso , Pitino Rosa , Ferrero Alice , Zavattaro Marco , Biello Federica , Gennari Alessandra , Mauro Sacchetti Gian , Aimaretti Gianluca , Prodam Flavia , Caputo Marina

Purpose: Diagnosis of adrenal lesions requires hormonal investigation and morphological characterization; when CT and MRI imaging are equivocal, 18F-FDG-PET/CT could be a useful tool, although sensitivity and specificity varied among cohorts. The use of tumour-to-liver maximum standardized uptake values (SUVratio) was found to be accurate, but the best threshold value has not been identified yet. A SUVratio > 1.5 was associated with malignancy with a good performance. The ...

ea0090ep727 | Pituitary and Neuroendocrinology | ECE2023

Prolactin-secreting pituitary adenoma: Clinical, radiological features and predictors of response to dopamine agonists

Romanisio Martina , Ferrero Alice , Daffara Tommaso , Catenazzi Sara , Pitino Rosa , Cavigiolo Beatrice , Zavattaro Marco , Marzullo Paolo , Caputo Marina , Prodam Flavia , Aimaretti Gianluca

Aim: Prolactinomas are the most frequent pituitary adenomas. Clear predictors of response to dopamine agonists (DA) are still discussed. The purpose of the study was to evaluate the clinical, radiological and hormonal characteristics of PRL-secreting pituitary adenomas, and to evaluate morphological changes over time and predictors of response to DA.Patients and Methods: Patients affected by PRL-secreting adenoma undergoing DA therapy in follow-up in a t...