Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep34 | Adrenal cortex (to include Cushing's) | ECE2017

The treatment with dual release hydrocortisone in patients with adrenal insufficiency: correlation between change of the evening cortisol exposure time profile and change in metabolic profile, depression status and quality of life

Simeoli Chiara , Ferrigno Rosario , Pivonello Claudia , Auriemma Renata Simona , Negri Mariarosaria , Di Gennaro Gilda , Iacuaniello Davide , De Martino Maria Cristina , Colao Annamaria , Pivonello Rosario

Conventional glucocorticoids (CGCs) are unable to mimic physiological cortisol rhythm in adrenal insufficiency (AI), resulting in increased metabolic morbidity and impaired quality of life (QoL). Non-physiological cortisol pattern and elevated evening cortisol levels may be responsible for the increased risk of metabolic disorders observed in AI patients under CGCs. Once daily dual-release-hydrocortisone (DR-HC), which better reproduces physiological daily cortisol profile, si...

ea0041gp17 | Adrenal (1) | ECE2016

Improved evening and nocturnal cortisol exposure time profile in patients with adrenal insufficiency treated with dual release hydrocortisone: correlation with improvement in metabolic profile

Simeoli Chiara , Ferrigno Rosario , De Martino Maria Cristina , Auriemma Renata Simona , Pivonello Claudia , Negri Mariarosaria , Iacuaniello Davide , Di Gennaro Gilda , Colao Annamaria , Pivonello Rosario

Conventional glucocorticoids (GCs) are unable to mimic physiological cortisol rhythm in adrenal insufficiency (AI), with a significant impact on morbidity and mortality. Possible explanations are supra-physiological doses and impaired cortisol profile. In particular, elevated evening cortisol levels were related to glucose tolerance and insulin sensitivity alterations and visceral obesity. Once-daily-dual-release-hydrocortisone (OD-DR-HC), better reproducing the physiological ...

ea0070aep10 | Adrenal and Cardiovascular Endocrinology | ECE2020

Cortisol rhythm in patients with adrenal insufficiency switched from conventional glucocorticoids to dual release hydrocortisone: Impact on metabolic profile

Simeoli Chiara , Iacono Marina , Ferrigno Rosario , Negri Mariarosaria , Pivonello Claudia , Simona Auriemma Renata , De Martino Maria Cristina , Colao Annamaria , Pivonello Rosario

Background: Several evidences suggested that conventional glucocorticoids (CGCs) used as replacement treatment in adrenal insufficiency (AI) are inadequate to mimic physiological cortisol circadian rhythm (CCR), and that CCR disruption, represented by non-physiological pattern of peaks and troughs and elevated evening GC levels, might be responsible for the increased metabolic and, consequently, cardiovascular risk. It has been demonstrated that once daily dual-release-hydroco...

ea0070aep341 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Anti-Lipogenic effects of cabergoline: A molecular study on white adipocytes

Negri Mariarosaria , Pivonello Claudia , Amatrudo Feliciana , Gentile Annalisa , Montò Tatiana , Patalano Roberta , Simeoli Chiara , Ferrigno Rosario , Simona Auriemma Renata , Colao Annamaria , Pivonello Rosario

Obesity is caused by an imbalance between dietary energy intake and expenditure. The expression of dopamine receptors (DRs) in human adipocytes has been already demonstrated. Moreover, the effects of cabergoline, a dopamine agonist, on body weight and glucose homeostasis in obese subjects without hyperprolactinemia has already been reported. The current study investigates the effects of cabergoline on lipid accumulation and on adipogenic factors expression to better define the...

ea0081p430 | Pituitary and Neuroendocrinology | ECE2022

Psychological impact of Covid-19 national lockdown on patients with Cushing’s syndrome in Italy: a case-control study

Di Paola Nicola , Barbot Mattia , Ferrante Emanuele , Ferrau Francesco , Gatto Federico , Maria Paragliola Rosa , Reimondo Giuseppe , Arnaldi Giorgio , Guarnotta Valentina , Ferrigno Rosario , Simeoli Chiara , Mantovani Giovanna , Scaroni Carla , Iasevoli Felice , Colao Annamaria , Pivonello Rosario

During the spring of 2020, a national lockdown was adopted in Italy to prevent COVID-19 pandemic spread. Restrictive measures have been associated with impaired psychological outcome in the general population. As patients with Cushing’s Syndrome (CS), including Cushing’s disease (CD), adrenal CS (ACS), and ectopic CS (ECS), are reportedly associated with a higher prevalence of anxiety, stress susceptibility, depression, and maniac episodes, during both active disease...

ea0070aep530 | Endocrine-related Cancer | ECE2020

Reversal effect of Vitamin D (VitD) on exosome-mediated everolimus resistance (EveR) in hepatocellular carcinoma (HCC) cell line: A molecular study

Gentile Annalisa , Negri Mariarosaria , Montò Tatiana , Patalano Roberta , de Angelis Cristina , Simeoli Chiara , Ferrigno Rosario , Cristina De Martino Maria , Simona Auriemma Renata , Colao Annamaria , Pivonello Rosario , Pivonello Claudia

Cancer exosomes emerged as important mediators of cancer drug resistance. Drug exposure-mediated EveR in HCC cell lines can be reversed by VitD pre- and co-treatment. The current study aimed to investigate whether cancer exosomes from EveR HCC cell line are able to induce EveR in parental cells and whether VitD may activate reversal effect on exosome-mediated EveR.To this purpose, parental JHH-6 and EveR JHH-6 cell line were used. The uptakeof exosomes, ...

ea0073yi1 | Young Investigator Awards | ECE2021

Circulating myomiRNAs as biomarkers of Cushing’s syndrome

Pivonello Claudia , Patalano Roberta , Negri Mariarosaria , Montò Tatiana , Amatrudo Feliciana , Paola Nicola Di , Iacono Marina , Simeoli Chiara , Ferrigno Rosario , Solari Domenico , Angelis Cristina De , Auriemma Renata Simona , Cappabianca Paolo , Colao Annamaria , Pivonello Rosario

Cushing’s syndrome (CS) is a rare endocrine disease caused by a chronic exposure to endogenous cortisol or exogenous glucocorticoids (GCs). Among multiple comorbidities, impairment of skeletal muscle mass and strength affects 40–70% of patients with active CS and persist even after long-term disease remission. In pathological conditions, GCs excess sustain muscle atrophy and weakness affecting type II muscle fibers. Muscle-specific microRNAs, defined myomiRs, are in...

ea0073aep412 | General Endocrinology | ECE2021

Psychological Impact of COVID-19 national lockdown meAsures on tRansgenDer people in Italy: The PICARD study

Ferrigno Rosario , Fattoruso Mariagrazia , Veneri Alessandra Delli , Cuccurullo Alessia , Falanga Daniela Lourdes , Amodeo Anna Lisa , Angelis Cristina De , Garifalos Francesco , Menafra Davide , Zarrilli Stefano , Iasevoli Felice , Vitelli Roberto , Colao Annamaria , Pivonello Rosario

During 2020 spring, national lockdown was adopted in Italy to prevent COVID-19 pandemic spread. Restrictive measures, including lockdowns, were associated with impaired psychological outcome, mainly increased perceived stress and anxiety, in general population. As transgender people (T*) are associated with higher prevalence of perceived stress, anxiety, and depression, higher psychological vulnerability during lockdowns cannot be excluded. The aim of the PICARD study was the ...

ea0063gp190 | Adrenal and Neuroendocrine - Clinical | ECE2019

Management and outcome of pregnancies in women with adrenal insufficiency: experience from a retrospective European study

Bothou Christina , Anand Gurpreet , Kienitz Tina , Seejore Khyatisha , Simeoli Chiara , Ward Emma G , Paragliola Rosa Maria , Ferrigno Rosario , Badenhoop Klaus , Bensing Sophie , Oksnes Marianne , Drake William , Wahlberg Jeanette , Reisch Nicole , Hahner Stefanie , Pearce Simon , Trainer Peter , Etzrodt-Walter Gwendolin , Thalmann Sebastien P , Saevik AEse B , Husebye Eystein , Isidori Andrea M , Falhammar Henrik , Meyer Gesine , Corsello Salvatore M , Pivonello Rosario , Murray Robert , Quinkler Marcus , Beuschlein Felix

Background and aims: Recommendations for the management of pregnancies in patients with adrenal insufficiency (AI) are scarce. The aim of this study was to analyse current clinical approaches in seventeen specialized centers across Europe with a particular focus on maternal and fetal outcome.Patients: 95 pregnancies in 86 patients with AI of different aetiology [Addison’s disease (n=37), secondary AI (n=22), congenital adrenal hype...