Searchable abstracts of presentations at key conferences in endocrinology

ea0056p1074 | Thyroid (non-cancer) | ECE2018

Metabolic signature of hypothyroidism indicating higher cardiovascular risk

Massarini Stefano , Ferrulli Anna , Luzi Livio

Hypothyroidism is associated with higher risk of cardiovascular disease and increase of blood lipids. Previous evidence indicates that high dosage of levothyroxine could be cardiotoxic. There are fewer data describing mortality in subjects after treatment and stabilization of thyroid diseases and there are no data related to subjects with treated hypothyroidism. Aim of this study was to investigate correlations between the cardiovascular risk and metabolic status [Resting Ener...

ea0063p353 | Thyroid 1 | ECE2019

Infrared thermography in association with indirect calorimetry: a new methodology for diagnosis and follow-up of subclinical hypothyroidism

Massarini Stefano , Natarelli Federica , Ferrulli Anna , Macri Concetta , Luzi Livio

Infrared Thermography (IT) is a non-invasive method and complementary to other diagnostic techniques to identify inhomogeneity of the thermal emission of the skin. We used IT (InfRec R500, Nippon Avionics Co.; 640×480 pixel, spatial resolution 0,87 mrad, sensitivity 0.03°C at 30°C, accuracy ±1°C) to assess the variations of skin temperature of the neck region: higher mean temperature, greater thyroid function. Primary outcome of this study was to compa...

ea0056oc6.2 | Genetic and environmental determinants of obesity and insulin resistance | ECE2018

Deep transcranial magnetic stimulation acutely modulates neuro-endocrine pathways underlying obesity

Ferrulli Anna , Adamo Michela , Massarini Stefano , Luzi Livio

Deep Transcranical Magnetic Stimulation (dTMS) is a non-invasive modulation technique of cortical excitability that has shown to affect the mesolimbic and mesostriatal dopaminergic pathways. Consistent with these assets, dTMS is widely used as a therapeutic tool in neuro-psychiatric disorders associated with abnormal cortical excitability and dopaminergic activity, as addiction. Hence, considering the dysfuncional role of PFC and dopaminergic reward system in controlling appet...

ea0081p586 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Weight loss variability with SGLT2 inhibitors, GLP-1 receptor agonists and repetitive Transcranial Magnetic Stimulation in Type 2 Diabetes and Obesity: results of a retrospective, comparative study

Ferrulli Anna , Massarini Stefano , Cannavaro Daniele , Perilli Paolo , Terruzzi Ileana , Senesi Pamela , Luzi Livio

Weight loss in individuals with Obesity (O) and Type 2 Diabetes (T2D), may improve glycaemic control and weight-related comorbidities, and in some cases, induce diabetes remission. However, body weight control is generally an unmet aim in this population. Thus, there is an increasing need to consider pharmacological approaches to assist weight loss in diabetes-obesity. Glucose-lowering agents as the sodium-glucose co-Transporter 2 inhibitors (SGLT2i) and GLP-1 Receptor Agonist...

ea0081ep442 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Regulation of glycemic variability in endothelial model: cross-talk between miRNAs and microfilaments in the activation of early fibrotic pathways

La Sala Lucia , Senesi Pamela , Capoitanio Daniele , Tagliabue Elena , Ferrulli Anna , Terruzzi Ileana , Luzi Livio

Glycemic variability (GV), a complex phenomenon affecting subjects with diabetes, is one of the main contributors to the risk to develop both acute and long-term complications in type 1 (T1D) and type 2 (T2D) subjects. DNA double-strand breaks, apoptosis, overgeneration of reactive oxygen species (ROS) and the induction of some regulatory micro-RNAs, sustain the ominous mechanisms mainly attributable to GV. The characteristic cellular phenotype induced by GV is scarcely define...

ea0063oc6.2 | Obesity | ECE2019

Deep Transcranial Magnetic Stimulation modulates body temperature in obesity

Ferrulli Anna , Massarini Stefano , Macri Concetta , Redaelli Veronica , Luzi Fabio , Luzi Livio

Obesity is known to be associated with increased heat production. To maintain normothermia, heat retention in areas of the body with greater adiposity is counteracted by an augmented heat release from the extremities, as the fingernail-beds of hands. A possible cause of the altered thermoregulation in obesity is a dysfunction of the neuro-endocrine system. Repetitive deep Transcranial Magnetic Stimulation (dTMS) was proved to be an effective tool in inducing long lasting chang...