Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep854 | Reproductive and Developmental Endocrinology | ECE2022

The kiss of metabolism and reproduction: is kisspeptin the key?

Poterasu Mihaela , Fica Simona

Background: The relationship between energy balance and reproduction is U-shaped, meaning that both a negative and a positive energy balance have a detrimental effect on reproductive function. In a world increasingly burdened by the growing prevalence of obesity, we turned our attention to the negative extremity of weight, by exploring anorexia nervosa (AN) and constitutional thinness (CT) metabolic and reproductive features. Kisspeptin (kiss-1) is a relatively recently discov...

ea0032p989 | Thyroid (non-cancer) | ECE2013

Influence of smoking on hyperthyroidism severity in newly diagnosed Graves' disease patients

Martin Sorina , Florea Suzana , Fica Simona

Introduction: Smoking is an independent risk factor for Graves’ disease (GD) and an independent predictor for Graves’ophtalmopathy (GO), but the influence on hyperthyroidism severity was not established.Aim: To evaluate the relationship between smoking and thyroid function at diagnosis and after administration of antithyroid drugs (ATDs) in GD patients.Materials and methods: We prospectively investigated 116 newly diagnos...

ea0081ep600 | Endocrine-Related Cancer | ECE2022

Sporadic metastatic pancreatic neuroendocrine tumor in a young patient

Mitrache Marius-Lucian , Martin Carmen Sorina , Nitipir Cornelia , Fica Simona

Background: Pancreatic neuroendocrine neoplasms (NENs) are rare tumors which can sometimes be diagnosed based on symptoms of hormone excess, but, more often, they are asymptomatic, and patients frequently present with metastatic disease. While they can occur in hereditary cancer syndromes such as multiple endocrine neoplasia type 1 (MEN1), von Hippel-Lindau (VHL), or neurofibromatosis (NF1), the majority of pancreatic NENs are sporadicCase report: We rep...

ea0081ep741 | Pituitary and Neuroendocrinology | ECE2022

Growth hormone deficiency due to a rare central nervous system tumor

Gabriela Duta Simona , Pavel Sebastian , Stoica Sergiu , Fica Simona

Introduction: Short stature is a common reason for pediatric endocrine evaluation and it can have a variety of causes, including constitutional, genetic short stature, dysmorphic syndromes, chronic illnesses and also endocrine disorders. Growth hormone deficiency accounts for 8% of the cases and it can be isolated or associated with other pituitary hormones deficiencies, congenital or acquired, such as in central nervous system tumors.Case report: A 15-y...

ea0063p274 | Pituitary and Neuroendocrinology 1 | ECE2019

Functioning gonadotroph adenoma in a 46 years old male

Pavel Mihai Lucian , Sirbu Anca Elena , Fica Simona

Introduction: Functioning gonadotroph adenomas (FGA) are adenomas secreting and expressing biologically active gonadotropins and causing distinct clinical manifestations. The vast majority of the immunohistochemically confirmed gonadotroph adenomas are hormonally silent (presenting only with mass effects), clinically FGA’s being very rare; whereas their exact prevalence is not known.Case study: A 46 years old male patient presents to our clinic afte...

ea0063p723 | Pituitary and Neuroendocrinology 2 | ECE2019

Elevated Chromogranin A levels in a patient with acromegaly – who is the culprit?

Mitrache Marius-Lucian , Leca Bianca , Martin Sorina , Fica Simona

Background: Chromogranin A (CgA) belongs to the family of granins, proteins which are an integral part of the secretory granules of neuroendocrine cells in endocrine glands and the diffuse neuroendocrine system. While it has become standard clinical practice to measure serum CgA in neuroendocrine tumors, various other non-endocrine conditions may increase this marker’s concentration and lead to diagnostic problems.Case report: We present the case of...

ea0049ep817 | Paediatric endocrinology | ECE2017

P3NP has high-normal values in GHD children and correlates negatively with IGF1

Costache Outas Mariana , Procopiuc Camelia , Caragheorgheopol Andra , Fica Simona

Aim: Procollagen type III N-terminal peptide (P3NP) occurs during type III collagen synthesis. Previous studies about the GH misuse in athletes proved the P3NP as a growth hormone (GH) responsive biomarker. We evaluate the P3NP levels and correlate with IGF1 depending on GH status.Subjects and Methods: We determined P3NP levels in 81 prepubertal children (35 girls) with a mean age of 6.2 y.o [3.37–9.95]. The group consists of 37 subjects with normal...

ea0041ep268 | Clinical case reports - Pituitary/Adrenal | ECE2016

Delayed diagnosis of isolated postpartum TSH deficiency: Sheehan’s syndrome or lymphocytic hypophysitis?

Iuliana Pascu , Minodora Betivoiu , Alexandra Nila , Sorina Martin , Simona Fica

Introduction: Sheehan’s syndrome (SS) is a rare complication of postpartum hemorrhage resulting in varying degrees of pituitary insufficiency. The diagnosis of SS has often been overlooked and thus delayed for many years due to its nonspecific signs and symptoms. Lymphocytic hypophysitis (LL) is also an uncommon autoimmune disorder that has to be suspected in women with recent delivery presenting with changes of one or more pituitary hormone secretions, especially when as...

ea0041ep292 | Clinical case reports - Pituitary/Adrenal | ECE2016

Congenital adrenal hyperplasia and multiple sclerosis: coincidence or not?

Betivoiu Minodora , Martin Sorina , Nila Alexandra , Pascu Iuliana , Fica Simona

Introduction: Congenital adrenal hyperplasia (CAH) is an inherited recessive disorder of adrenal steroidogenesis, generally caused by total or partial deficiency in 21-hydroxylase, due to deletions or mutations of CYP21 gene. Some studies suggest that the association between CAH and multiple sclerosis (MS) could be nonincidental: a possible MS susceptibility locus is on chromosome 6p21, on which the CYP21 gene is located.We report the c...

ea0041ep389 | Clinical case reports - Thyroid/Others | ECE2016

Graves’ orbitopathy- When the going gets tough… the tough get going?

Nila Alexandra , Betivoiu Minodora , Serbanescu Cristina , Martin Sorina , Fica Simona

Introduction: Thyroid disorders are common within the elderly population and are particularly challenging to diagnose and treat due to the presence of a wide variety of comorbidities. Graves’ ophtalmopathy remains a therapeutic predicament despite all progress made in understanding its pathogenesis, especially in the elderly population with severe presentation.Case presentation: We present the case of a 71-years-old female patient who was admitted i...