Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep854 | Reproductive and Developmental Endocrinology | ECE2022

The kiss of metabolism and reproduction: is kisspeptin the key?

Poterasu Mihaela , Fica Simona

Background: The relationship between energy balance and reproduction is U-shaped, meaning that both a negative and a positive energy balance have a detrimental effect on reproductive function. In a world increasingly burdened by the growing prevalence of obesity, we turned our attention to the negative extremity of weight, by exploring anorexia nervosa (AN) and constitutional thinness (CT) metabolic and reproductive features. Kisspeptin (kiss-1) is a relatively recently discov...

ea0032p989 | Thyroid (non-cancer) | ECE2013

Influence of smoking on hyperthyroidism severity in newly diagnosed Graves' disease patients

Martin Sorina , Florea Suzana , Fica Simona

Introduction: Smoking is an independent risk factor for Graves’ disease (GD) and an independent predictor for Graves’ophtalmopathy (GO), but the influence on hyperthyroidism severity was not established.Aim: To evaluate the relationship between smoking and thyroid function at diagnosis and after administration of antithyroid drugs (ATDs) in GD patients.Materials and methods: We prospectively investigated 116 newly diagnos...

ea0081ep600 | Endocrine-Related Cancer | ECE2022

Sporadic metastatic pancreatic neuroendocrine tumor in a young patient

Mitrache Marius-Lucian , Martin Carmen Sorina , Nitipir Cornelia , Fica Simona

Background: Pancreatic neuroendocrine neoplasms (NENs) are rare tumors which can sometimes be diagnosed based on symptoms of hormone excess, but, more often, they are asymptomatic, and patients frequently present with metastatic disease. While they can occur in hereditary cancer syndromes such as multiple endocrine neoplasia type 1 (MEN1), von Hippel-Lindau (VHL), or neurofibromatosis (NF1), the majority of pancreatic NENs are sporadicCase report: We rep...

ea0081ep741 | Pituitary and Neuroendocrinology | ECE2022

Growth hormone deficiency due to a rare central nervous system tumor

Gabriela Duta Simona , Pavel Sebastian , Stoica Sergiu , Fica Simona

Introduction: Short stature is a common reason for pediatric endocrine evaluation and it can have a variety of causes, including constitutional, genetic short stature, dysmorphic syndromes, chronic illnesses and also endocrine disorders. Growth hormone deficiency accounts for 8% of the cases and it can be isolated or associated with other pituitary hormones deficiencies, congenital or acquired, such as in central nervous system tumors.Case report: A 15-y...

ea0084ps1-05-46 | Miscellaneous | ETA2022

Body composition determinants of thyroid function and volume in euthyroid patient with obesity

Sirbu Anca , Busuioc Denisa , Martin Sorina , Barbu Carmen , Fica Simona

The aim of our study was to investigate de relationship between anthropometric and body composition parameters and thyroid function (measured with TSH and free T4), as well as thyroid volume, in patients with obesity.Methods: This is a cross-sectional study including patients with obesity consecutively referred to our tertiary endocrine center for diverse pathologies. TSH and free T4 was measured in all patients and thyroid ultrasound was performed by an...

ea0086p57 | Metabolism, Obesity and Diabetes | SFEBES2022

Parameters associated with neutrophil to lymphocyte ratio in patients with severe obesity

Sirbu Anca , Martin Sorina , Soare Iulia , Manaila Mihaela , Fica Simona

Obesity has been associated with a status of subclinical inflammation. Neutrophil to lymphocyte ratio (NRL) is a widely available and inexpensive inflammatory marker which can be reliable in evaluating the inflammatory status occurring in patients with severe obesity The aim of our study was to investigate the association between NLR and anthropometric and body-composition parameters, in a group of patients with obesityPatients and Methods: 737 patients ...

ea0090ep14 | Adrenal and Cardiovascular Endocrinology | ECE2023

Paraganglioma mimicking a tumor of the liver in an elderly patient

Pana Monica-Mirela , Sirbu Anca , Popa Miruna Maria , Fica Simona

Introduction: Paragangliomas are neuroendocrine tumors that are derived from the embryonic neural crest cells. Because the paraganglia are widespread through the body, paragangliomas can be found in unusual anatomic locations and the diagnosis can be hard to establish. Case presentationWe present the case of an 72 year-old, hypertensive woman who arrived at the hospital for pain in the right hypochondrium. General examination revealed an abdomen without signs of peritoneal irr...

ea0090ep1042 | Thyroid | ECE2023

Navigating the differential diagnosis of thyrotropinoma and resistance to thyroid hormones

Niculaide Cristina , Mustata Theodor , Sorina Martin Carmen , Fica Simona

Introduction: Syndrome of inappropriate secretion of thyrotropin (SITSH) is a rare condition characterized by uninhibited serum TSH in the presence of high thyroid hormones, usually caused by TSH secreting adenoma or resistance to thyroid hormones (RTH). Differential diagnosis between the two is often challenging due to their overlapping features.Case report: We present the case of a 50-year-old postmenopausal woman with a history of -myocardial infarcti...

ea0063p274 | Pituitary and Neuroendocrinology 1 | ECE2019

Functioning gonadotroph adenoma in a 46 years old male

Pavel Mihai Lucian , Sirbu Anca Elena , Fica Simona

Introduction: Functioning gonadotroph adenomas (FGA) are adenomas secreting and expressing biologically active gonadotropins and causing distinct clinical manifestations. The vast majority of the immunohistochemically confirmed gonadotroph adenomas are hormonally silent (presenting only with mass effects), clinically FGA’s being very rare; whereas their exact prevalence is not known.Case study: A 46 years old male patient presents to our clinic afte...

ea0063p723 | Pituitary and Neuroendocrinology 2 | ECE2019

Elevated Chromogranin A levels in a patient with acromegaly – who is the culprit?

Mitrache Marius-Lucian , Leca Bianca , Martin Sorina , Fica Simona

Background: Chromogranin A (CgA) belongs to the family of granins, proteins which are an integral part of the secretory granules of neuroendocrine cells in endocrine glands and the diffuse neuroendocrine system. While it has become standard clinical practice to measure serum CgA in neuroendocrine tumors, various other non-endocrine conditions may increase this marker’s concentration and lead to diagnostic problems.Case report: We present the case of...