ea0070aep6 | Adrenal and Cardiovascular Endocrinology | ECE2020
Vaczlavik Anna
, Bouys Lucas
, Letouze Eric
, Perlemoine Karine
, Guignat Laurence
, Letourneur Franck
, Sibony Mathilde
, Bonnet Fidéline
, Heurtier Victor
, Espiard Stéphanie
, Assié Guillaume
, Ragazzon Bruno
, Bertherat Jerome
Introduction: Primary bilateral macronodular adrenal hyperplasia (PBMAH) are benign adrenocortical disease responsible for benign tumors and cortisol autonomous secretion. There is a broad spectrum of clinical, imaging and hormonal presentations. Aberrant membrane receptor expression is frequent, the most characteristic example being the food dependent Cushing syndrome due to ectopic expression of the GIP receptor (GIP-R). In 20 to 25 % of these patients, inactivating heterozy...