Searchable abstracts of presentations at key conferences in endocrinology

ea0081p615 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Is age-related hepatic elevation of endogenous SERM 27-hydroxycholesterol associated with hepatocellular degeneration female-specific? − Results from Rat study

S.ošić-Jurjević Branka , Jovanović Ljubiša , Marina Ljiljana , Ristic Natasa , Miler Marko , Ajdžanović Vladimir , Filipović Branko , Luetjohann Dieter

The cholesterol oxidation product 27-hydroxycholesterol (27OHC) is enzymatically produced from cholesterol by CYP27A1 in an alternative pathway of cholesterol degradation to bile acids. This oxysterol also acts as an endogenous selective estrogen receptor modulator (SERM). In healthy humans its concentration in circulation increases in hypercholesterolemia and with age, and is associated with increased risk of atherosclerosis, cardiovascular diseases and breast cancer. Several...

ea0081p477 | Thyroid | ECE2022

The effects of aging on thyroid C-cells in male rats

Filipović Branko , Ajdžanović Vladimir , Živanović Jasmina , Manojlović-Stojanoski Milica , Trifunovć Svetlana , Nestorović Nataša , Šošić-Jurjević Branka

Thyroid C-cells, as a second type of endocrine cell population within thyroid, produce and secrete peptide hormone calcitonin (CT). This hypocalcemic hormone acts as an inhibitor of bone resorption. The aging is a complex process that alters various cellular functions. Therefore, the aim of this study was to examine the aging-related changes in the structure and function of CT-producing thyroid C-cells in male Wistar rats, using histomorphometric, ultrastructural and biochemic...

ea0049ep172 | Endocrine tumours and neoplasia | ECE2017

A nomogram consisted of routine biochemical tests may increase the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine tumors

Vurnek Ivan , Kruljac Ivan , Ćaćić Miroslav , Perić Božidar , Filipović-Grčić Maja , Mirošević Gorana , Kust Davor , Vrkljan Milan

Introduction: Falsely elevated serum chromogranin A (CgA) is associated with the use of proton pump inhibitors, the presence of renal impairment and systemic inflammation. We aimed to investigate which laboratory parameters are independently associated with increased CgA and to develop a nomogram, in order to improve the diagnostic accuracy of CgA in detecting patients with neuroendocrine tumors (NET).Methods: Our retrospective study included 155 subject...

ea0049ep212 | Bone & Osteoporosis | ECE2017

Salmon calcitonin affects thyroid endocrine cells and trabecular bone in a rat model of male osteoporosis

Filipović Branko , Šošić-Jurjević Branka , Živanović Jasmina , Manojlović-Stojanoski Milica , Nestorović Nataša , Trifunović Svetlana , Jarić Ivana , Ušćebrka Gordana , Milošević Verica

Calcitonin (CT) is a hypocalcemic hormone produced by thyroid C-cells that acts as an bone antiresorptive agent. The other endocrine cell population in thyroid, called follicular cells produce thyroid hormones (TH) which also affect bone turnover. In this study, we evaluated the effects of salmon CT administration on structure and function of both CT and TH producing thyroid cells as well as trabecular bone microarchitecture in orchidectomized (Orx) middle-aged rats. Fifteen-m...

ea0049ep359 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Soybean phytoestrogens reduce 27-hydroxycholesterol concentration in the liver of middle-aged female rats

Šošić-Jurjević Branka , Janković Snežana , Lutjohann Dieter , Jarić Ivana , Miler Marko , Filipović Branko , Ajdžanović Vladimir , Milošević Verica

Hypercholesterolemia is associated with athero-thrombotic disease, a leading cause of mortality worldwide. Advances in both dietary and pharmacological interventions contribute to prevention and treatment of modifiable risk factors.Purified soybean phytoestrogens, isoflavones genistein (GEN) and daidzein (DAI), were reported to exert moderate cholesterol-lowering effect. In this research first we studied age-related modifications in hepatic cholesterol metabolism and serum est...

ea0049ep463 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Incidence of diabetic ketosis and ketoacidosis in Caucasian adults with type 2 diabetes mellitus: a population-based study

Ćaćić Petra , Kruljac Ivan , Ćaćić Miroslav , Perić Božidar , Filipović-Grčić Maja , Mirošević Gorana , Vrkljan Milan

Aims: Diabetic ketosis (DK) and diabetic ketoacidosis (DKA) are known complications of type 1 diabetes mellitus (T1DM). However, DK and DKA have been described in T2DM. Referred to as ketosis-prone T2DM, this subtype of T2DM has been described in Hispanics and Afro-Americans of sub-Saharan Africa, but the incidence and pathogenesis remains unknown. We aimed to analyze characteristics of patients with diabetic ketosis (DK) and diabetic ketoacidosis (DKA) in Ca...

ea0049ep549 | Diabetes complications | ECE2017

Prognostic factors and all-cause mortality in patients with type 2 diabetes presenting with diabetic ketoacidosis: a population based, case-control study

Ćaćić Petra , Ćaćić Miroslav , Kruljac Ivan , Perić Božidar , Filipović-Grčić Maja , Mirošević Gorana , Vrkljan Milan

Introduction: Little is known about diabetic ketoacidosis (DKA) in type 2 diabetes mellitus (T2DM). Moreover, the clinical impact of diabetic ketosis (DK) in T2DM is elusive. The aim of this study was to analyze characteristics and mortality of patients with DKA and DK and to identify possible prognostic factors.Methods: This was a population-based, cross-sectional study that included all patients with T2DM presenting to emergency department with DKA, ov...