Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp196 | Thyroid - Basic | ECE2016

Determination of thyroid hormones in small amount of mouse tissue sample using new isotope-dilution liquid chromatography-mass spectrometry method

De Angelis Meri , Finan Brian , Clemmensen Christoffer , Mueller Timo , Tschoep Matthias , Giesert Florian , Schramm Karl-Werner

Thyroid hormones (THs) play a critical role in the regulation of growth and development in both animals and humans. They regulate metabolism primarily through actions in the brain, white fat, brown fat, skeletal muscle, liver and pancreas. Therefore, it is not surprising that since a long time scientists have been interested in measuring TH concentration in different tissues and to relate this value with possible dysfunctions. In general, TH levels are measured by immunoassay ...

ea0041oc12.4 | Obesity | ECE2016

GLP-1 directed delivery of dexamethasone ameliorates hypothalamic inflammation and reverses diet-induced obesity

Quarta Carmelo , Clemmensen Christoffer , Yang Bin , Zhu Zhimeng , Muller Timo D , DiMarchi Richard D , Finan Brian , Tschop Matthias H

Abstract: Inflammation plays a contributing role in the pathogenesis of several metabolic disorders, including type 2 diabetes and obesity. Intriguingly, obesogenic diets induce markers of hypothalamic inflammation and neuronal injury in both rodents and humans, suggesting that targeting inflammatory pathways in the hypothalamus might represent a novel strategy to control energy metabolism. Unfortunately, the majority of steroid-based anti-inflammatory drugs are fraught with a...

ea0049oc2.3 | Diabetes Prediction and Complications | ECE2017

GLP-1 based multi-agonists-induced signaling includes profound TRP channel involvement in insulin secretion

Khajavi Noushafarin , Finan Brian , Kluth Oliver , Mergler Stefan , Muller Timo , Kleinau Gunnar , Schurmann Annette , Tschop Matthias H , DiMarchi Richard , Krude Heiko , Biebermann Heike

Promiscuous multi-agonists that simultaneously activate two or three key receptors (incretin- and/or glucagon receptor) were recently shown to improve glycemic control in mice. Here we investigated the underlying mechanisms of multi-agonists to enhance insulin secretion in murine islets and human pancreatic β-cells. These mixed agonists display a greater potency in cAMP signaling as compared to the native incretins. However, pharmacological blockade of cAMP signaling only...

ea0070ep169 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Peripheral cannabinoid–1 receptor blockade potentiates the anti–obesity and anti–diabetic effects of GLP–1 mimetics

Zizzari Philippe , He Rongjun , Bellocchio Luigi , Allard Camille , Clark Samantha , Thierry Leste–lasserre , Marsicano Giovanni , Perez–Tilve Diego , Finan Brian , Cota Daniela , Quarta Carmelo

Obesity and type–2 diabetes (T2D) represent a global health crisis. However, only a few, and often sub–effective pharmacological tools are available to treat these disorders. Though beneficial for glycemic control, GLP–1 receptor (GLP–1R) agonists show scarce weight–lowering and insulin–sensitizing efficacy.New molecules able to selectively block the activity of the cannabinoid receptor type–1 (CB1R) in periphera...