Searchable abstracts of presentations at key conferences in endocrinology

ea0020p8 | Adrenal | ECE2009

Effect of universal somatostatin analog (SOM230) on primary adrenal cell cultures

Mariniello Barbara , Finco Isabella , Rubin Beatrice , Patalano Anna , Ferasin Sergio , Iacobone Maurizio , Fassina Ambrogio , Mantero Franco

Introduction: Somatostatin (SST) is a widely distributed polypeptide that modulates the endocrine and exocrine secretion, cellular proliferation and differentiation, and apoptosis via G protein-linked receptors. Our previous studies showed high SSTR expression in adrenocortical carcinoma (ACC), aldosterone producing adenoma (APA) and in cortisol producing adenoma (CPA). Only very few information are available about the effectiveness of SST analogs in adrenal tumors.<p clas...

ea0016p19 | Adrenal | ECE2008

Angiogenic status of human adrenocortical tumors

Mariniello Barbara , Sartorato Paola , Finco Isabella , Patalano Anna , Iacobone Maurizio , Mantero Franco

Introduction: Angiogenesis plays a major role in cancer growth and metastasis. Differences in angiogenesis and the balance of angiogenic growth factors and inhibitors may play a role in determining the observed variations in tumor behaviour. VEGF overexpression in adrenocortical carcinomas (AC) has been recently shown. Moreover a new steroidogenic specific tissue angiogenic factor (EG-VEGF) has been described, and its role is presently unknown in adrenal tumors. Previous evide...