Searchable abstracts of presentations at key conferences in endocrinology

ea0081p331 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Increasing overrepresentation of diabetes in non-traumatic lower limb amputations

Eik-Nes Sindre , Valland Susanna , Talsnes Ove , Ostlie Kristin , Holvik Kristin , Elisabeth Finnes Trine

Background and Aim: Recent international studies indicate a secular decrease in the proportion of patients with diabetes who undergo lower limb amputations (LLA), and the same trend is observed in the national quality indicator. The validity of electronic databases and quality indicators are limited by multiple discharges and precision of coding. Furthermore, amputation codes included in the quality indicator do not include all amputations. We therefore aim to investigate the ...

ea0090p616 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Gender differences in lower limb amputations among persons with diabetes

Elisabeth Finnes Trine , Valland Susanna , Talsnes Ove , Eik-Nes Sindre , Holvik Kristin

Background and Aim: Recent international studies indicate a secular decrease in the proportion of patients with diabetes who undergo lower limb amputations (LLA). However, our findings suggest that the proportion of diabetics among patients undergoing non-traumatic, non-cancer related lower limb amputations has increased over the past decades despite comprehensive preoperative investigations and other surgical interventions. To further explore the underlying reasons for this, ...

ea0063p431 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Residual adrenocortical function in autoimmune addison’s disease: interim results of a cross-sectional study

Saevik AEse Bjorvatn , AEkermann Anna-Karin , Methlie Paal , Gunnar Nedrebo Bjorn , Dahle Anne Lise , Carlsen Siri , Tomkowicz Aneta , Holte Synnove Emblem , Debowska Aleksandra , Sollid Stina Therese , Jorgensen Anders , Nermone Ingrid , Gronning Kaja , Finnes Trine , Grimnes Guri , Hoybye Charlotte , Skov Jakob , Dahlqvist Per , Wahlberg Jeanette , Isaksson Magnus , Quinkler Marcus , Bensing Sophie , Oksnes Marianne , Husebye Eystein

Background: Current dogma states that in autoimmune AddisonÂ’s disease (AAD), all adrenocortical function eventually is lost. Yet growing evidence suggests that a subgroup of patients retain some self-production.Aim: To explore whether residual production of adrenocortical steroids is present in a subgroup of AAD patients.Material and methods: In an open non-randomized cross-sectional study, an interim of 22 AAD patients delive...

ea0070aep1 | Adrenal and Cardiovascular Endocrinology | ECE2020

Residual corticosteroid production in autoimmune addison´s disease

Bjorvatn Saevik Åse , Åkerman Anna-Karin , Methlie Paal , Quinkler Marcus , Palmström Jörgensen Anders , Höybye Charlotte , Debowska Aleksandra J , Gunnar Nedrebø Bjørn , Lise Dahle Anne , Carlsen Siri , Tomkowicz Aneta , Therese Sollid Stina , Nermoen Ingrid , Grønning Kaja , Dahlqvist Per , Grimnes Guri , Skov Jakob , Finnes Trine , Valland Susanna F , Wahlberg Jeanette , Emblem Holte Synnøve , Simunkova Katerina , Kämpe Olle , Sverre Husebye Eystein , Bensing Sophie , Øksnes Marianne

Background: Previous research show that autoimmune adrenal insufficiency develops gradually over time and inexorably results in a total inability to produce adrenal steroids. However, growing evidence suggest that a few patients preserve some steroid producing capacity.Aim: To explore the frequency of residual cortisol production and possible clinical consequences in patients with autoimmune Addison´s disease (AAD).Material an...

ea0073aep4 | Adrenal and Cardiovascular Endocrinology | ECE2021

Biomarkers of cardiovascular disease and inflammation in autoimmune addison’s disease with residual adrenocortical function

Åse Bjorvatn Sævik , Anna-Karin Åkerman , Methlie Paal , Quinkler Marcus , Anders Jørgensen , Charlotte Höybye , Debowska Aleksandra , Bjørn Gunnar Nedrebø , Dahle Anne Lise , Carlsen Siri , Tomkowicz Aneta , Synnøve Holte , Sollid Stina Therese , Nermoen Ingrid , Kaja Grønning , Dahlqvist Per , Grimnes Guri , Skov Jakob , Finnes Trine , Valland Susanna , Wahlberg Jeanette , Simunkova Katerina , Olle Kämpe , Husebye Eystein Sverre , Bensing Sophie , Marianne Øksnes

BackgroundResidual adrenocortical function (RAF) is present in one third of patients with autoimmune AddisonÂ’s disease (AAD), yet its clinical significance remains unknown.ObjectiveTo investigate if biomarker profiles of cardiovascular disease and inflammation are different in patients with AAD and RAF compared to patients without RAF and healthy controls.Material and methods<p...