Searchable abstracts of presentations at key conferences in endocrinology

ea0015p293 | Reproduction | SFEBES2008

Desensitisation of oxytocin receptors with labour-onset in isolated human myometrium

Fischer Deborah , Farrar Diane , O'Donovan Peter , Woodward David , Marshall Kay

Although oxytocin is a potent stimulant of myometrial contractions, its role in parturition is controversial. The aim of the present study was to elucidate the functional mechanisms of oxytocin receptors in isolated human myometrium before and after labour-onset.Myometrial biopsies were obtained from consenting women (aged 21–34 years) undergoing Caesarean section at term pregnancy, not in labour (n=6), or in early (n=6) or late (n<...

ea0016p637 | Reproduction | ECE2008

Topographical effects of functional prostanoid and oxytocin receptors on mid-cycle contractions in isolated human myometrium

Fischer Deborah , O Donovan Peter , Farrar Diane , Woodward David , Marshall Kay

Dysfunctional prostanoid and oxytocin receptors have been implicated in the development of myometrial hyperactivity, causing dysmenorrhoea and infertility. The aim of the present study was to investigate the topographical differences in functional contractile PG and oxytocin receptors in mid-cycle isolated myometrium.Longitudinal, full-thickness sections of the anterior uterus were obtained from consenting pre-menopausal donors (aged 39–48 years) un...

ea0013p263 | Reproduction | SFEBES2007

EP2-mediated reduction of oxytocin-induced activity in term pregnant human myometrium

Fischer Deborah , Marshall Kay , Duckworth Nicola , Farrar Diane , O’Donovan Peter , Woodward David

Both prostaglandin (PG) E2 and oxytocin are used clinically in the induction of labour. However, the functional co-expression of inhibitory PGE2 receptors (EP2) and contractile oxytocin receptors in lower segment myometrium is not fully understood. The aim of the present study was to elucidate EP2 agonist effects on oxytocin-induced myogenic contractions and to identify their combined action on intracellular calcium (Ca2+)...