Endocrine Abstracts

Introduction: Klinefelter syndrome has been associated with decreased bone density most likely due to testosterone deficiency. Furthermore, a negative effect of long-lasting follicle-stimulating hormone (FSH) excess (starting from puberty) on trabecular bone has been suggested. Other endocrine mechanisms, such as global Leydig cell dysfunction, higher oestradiol levels, altered 25-OH vitamin D levels, and genetic aspects related to the supernumerary X chromosome might be invol...