Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep846 | Paediatric endocrinology | ECE2016

Pharmacokinetic and pharmacodynamic modeling of long acting human growth hormone (MOD-4023) in growth hormone deficient children

Fisher Dennis M. , Jaron-Mendelson Michal , Amitzi Leanne , Koren Ronit , Hart Gili

Introduction: OPKO Biologics has produced a long-acting human growth hormone (hGH), MOD-4023, containing three copies of a naturally-occurring peptide (C-terminal peptide, CTP) that markedly increases growth hormone’s in vivo residence. We describe the development and validation of a pharmacokinetic (PK) and pharmacodynamic (PD) model to characterize the relationship between MOD-4023 dose, serum concentrations (Cserum), and IGF-1 responses in healthy adults, GHD adults, a...