Endocrine Abstracts

Background: Glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2), are key products of the L-cell proglucagon-gene with diverse effects on metabolism. Whereas GLP-1 has been extensively studied, much less attention has been devoted to GLP-2. The current study directly compares the impact of GLP-1 and GLP-2 on pancreatic beta-cell function and turnover in vitro, as well as the effects on glucose tolerance and appetite suppression in mice.<p class="abs...

Recent acute in vivo studies have shown that structural modifications of dogfish glucagon improves peptide stability and these analogues can act as dual agonists at both glucagon and GLP-1 receptors. Here, we compared the effects of chronic (51 days) twice daily administration of [D-Ala2]dogfish glucagon (Pep-N) and [D-Ala2]dogfish glucagon-exendin-4(31–39) construct (Pep-C), exendin-4(1–39) or saline treat...

Aim: Insulin-releasing effects and potential anti-diabetic actions of peptides isolated from the skin secretion of the African clawed frog, Xenopus amieti has been reported. However, peptides such as magainin-AM1 has not been previously studied for its ability to stimulate insulin secretion or promote glucose uptake. This study investigated insulin releasing effects as well as possible underlying mechanisms.Methods: Acute and chronic actions of ...

Background/aims: Obesity is a major risk factor for endometrial cancer with estrogens in combined oral contraceptives enhancing the severity of the disease. This study aims to explore the effect of synthetic estrogen ethinylestradiol (EE2) commonly used in oral contraceptives, on endometrial morphology and regulatory markers in diet-induced obese mice.Methods: Female TO mice were on a high-fat diet (HFD) for 27 weeks. Three groups (n = 5) were g...

Background: Pregnancy induces pancreatic islet β-cell mass expansion, but the exact mechanisms responsible remain unclear. It is nevertheless believed that disturbances in the process contribute to the development of gestational diabetes. The current study investigates the impact of pregnancy and cafeteria diet on islet morphology, cellular proliferation/apoptosis as well as endocrine cell lineage plasticity. Methods: Non-pregnant and pregnant Ins<e...