Searchable abstracts of presentations at key conferences in endocrinology

ea0065s4.2 | Thyroid hormone a key regulator in inflammation | SFEBES2019

Thyroid hormone in inflammation

van der Spek Anne H , Fliers Eric , Boelen Anita

Thyroid hormone levels are strongly affected by inflammation. In a wide spectrum of diseases, ranging from critical illness in the ICU to ischemic stroke, a decrease in circulating T3 and T4 is observed without the expected increase in TSH. This disruption of the negative feedback system of the hypothalamic–pituitary–thyroid (HPT) axis is accompanied by various changes in thyroid hormone metabolism at the cellular and tissue level. C...

ea0020p65 | Thyroid | ECE2009

Prevalence of growth hormone deficiency in autoimmune hypothyroidism

Eskes Silvia , Endert Erik , Fliers Eric , Wiersinga Wilmar

Background: Autoimmune hypophysitis can result in growth hormone deficiency (GHD). Although autoimmune hypophysitis is uncommon, it is associated with other autoimmune endocrine diseases like autoimmune hypothyroidism (AIH). Recent studies suggest a high prevalence (5%) of GHD in AIH, which could contribute to the reduced quality of life frequently observed in patients with AIH despite adequate treatment with thyroxine.Objective: To establish the prevale...

ea0022s2.1 | Endocrine aspects about the metabolic syndrome | ECE2010

Brain–adipose and brain–liver connections in the metabolic syndrome

Fliers Eric , Klieverik Lars , Yi Chun-Xia , Ackermans Mariette , Kalsbeek Andries

Pre-autonomic neurons in the hypothalamic paraventricular nucleus (PVN) project to sympathetic and parasympathetic motor nuclei in the brain stem, from where the liver and white adipose tissue (WAT) are innervated by both branches of the autonomic nervous system (ANS). Studies by our group and by others have shown that these neural pathways modulate glucose and lipid metabolism in liver and WAT. Given the abundant thyroid hormone receptor (TR) expression in the PVN we hypothes...

ea0022h2.5 | Oral Communications Highlights 2 | ECE2010

Effects of leptin administration on starvation-induced alterations in hepatic thyroid hormone metabolism in mice

Boelen Anita , Van Beeren Mieke , Vos Xander , Surovtseva Olga , Kwakkel Joan , Fliers Eric

Fasting induces profound metabolic changes in order to decrease energy expenditure and to conserve energy. One of the major adaptations is downregulation of the hypothalamus–pituitary–thyroid (HPT) axis, characterized by decreased serum thyroid hormone levels without an increase in serum TSH or in TRH expression in the hypothalamic paraventricular nucleus (PVN). Leptin has been proposed as a critical signal initiating the neuroendocrine response to fasting as it decr...

ea0056gp274 | Thyroid non cancer - Benign Thyroid disease/ treatment | ECE2018

Reduced quality of life and persistent complaints in treated hypothyroid patients

Molewijk Ellen , Martens Maayan , Fliers Eric , Zelissen Pierre , Dreijerink Koen , van Dooren Ad , Heerdink Rob

Background: Hypothyroidism is a common endocrine disorder and the standard treatment is replacement therapy with levothyroxine (LT4). Although many hypothyroid patients improve upon treatment with LT4, a proportion seems to experience residual hypothyroid complaints despite treatment, even when plasma TSH and FT4 are within reference ranges.Methods: Using an on-line survey we investigated i) the health-related quality of life (QoL) (ThyPRO), ii) the acti...

ea0063gp235 | Anterior and Posterior Pituitary | ECE2019

The effect of previous optic chiasm compression on the post-illumination pupil response in pituitary patients

Boertien Tessel , Meijden Wisse van der , Coumou Adriaan , Drent Madeleine , Someren Eus Van , Romijn Hans , Fliers Eric , Bisschop Peter

Rationale: A history of optic chiasm compression in patients treated for sellar tumors is associated with alterations in sleep-wake rhythm. The optic chiasm contains axons of intrinsically photosensitive retinal ganglion cells (ipRGCs) that mediate photoentrainment of the suprachiasmatic nucleus. Compression could disrupt this entrainment leading to desynchronization with the 24-hour light-dark cycle. The post-illumination pupil response (PIPR) after blue light exposure is a u...

ea0037oc5.5 | Steroids, developmental and paediatric endocrinology | ECE2015

Pituitary hormone secretion profiles in IGSF1 deficiency syndrome

Joustra Sjoerd , Roelfsema Ferdinand , Endert Erik , Ballieux Bart , van Trotsenburg Paul , Fliers Eric , Corssmit Noortje , Bernard Daniel , Oostdijk Wilma , Wit Jan-Maarten , Pereira Alberto , Biermasz Nienke

Context: Loss-of-function of immunoglobulin superfamily 1 (IGSF1) causes an X-linked syndrome of central hypothyroidism, macroorchidism, and variable prolactin deficiency, GH deficiency in childhood, delayed pubertal testosterone rise, and/or obesity. The clinical features advert towards a pivotal role for IGSF1 in the pituitary gland, but detailed knowledge on pituitary hormone secretion in this syndrome is lacking.Objective: To study detailed ...

ea0070aep595 | Pituitary and Neuroendocrinology | ECE2020

Gallium-68 -DOTATATE PET imaging in clinically non-functioning pituitary macroadenomas

M. Boertien Tessel , Booij Jan , Majoie Charles BLM , Drent ML , Pereira Alberto M , Biermasz Nienke , Simsek Suat , Groote Veldman Ronald , Stokkel Marcel PM , Bisschop Peter H , Fliers Eric

Background: Clinically non-functioning pituitary macroadenomas (NFMA) have been reported to express various somatostatin receptor (SSTR) subtypes, but results are inconsistent across different studies. This may be related to limited sensitivity and specificity of techniques used to date, i.e. immunohistochemistry in surgical specimens and 111In-DTPA-octreotide scintigraphy (Octreoscan) in vivo. The aim of this study was to assess SSTR expression in NFMA <em...

ea0063gp153 | Cushing's | ECE2019

Evaluation of the corticotrophin-releasing-hormone test and the high dose dexamethasone suppression test in ACTH dependent Cushing’s syndrome: a 25-year prospective cohort study

Muller Dion R.P. , Gent-Houben Moniek C.F. , van Vessem-Timmermans Martine , Linthorst Gabor E. , Serlie Mireille J. , Siegelaar Sarah E. , Soeters Maarten R. , Hillebrand Jacquelien J. , Heijboer Annemieke C. , Fliers Eric , Bisschop Peter H. , Jan Stenvers Dirk

Introduction: In patients with ACTH-dependent hypercortisolism, the corticotropin-releasing-hormone (CRH) test and the high dose dexamethasone suppression test (HDDST) can be used to differentiate between pituitary ACTH production (Cushing’s disease) and ectopic ACTH production. The rationale is that a pituitary adenoma will show some response to CRH and ACTH whereas an ectopic source is less responsive to ACTH and CRH. However, there is discussion about the clinical util...

ea0070ep340 | Pituitary and Neuroendocrinology | ECE2020

The galant trial: a randomised placebo-controlled trial in patients with a gallium-68 dotatate pet positive, clinically non-functioning pituitary macroadenoma on the effect of lanreotide on tumour size

Boertien Tessel M. , Drent M.L. , Booij Jan , Majoie Charles B.L.M. , Stokkel Marcel P.M. , Hoogmoed Jantien , Pereira Alberto M , Biermasz Nienke , Simsek Suat , Veldman Ronald Groote , Tanck Michael W.T. , Fliers Eric , Bisschop Peter H.

Rationale: At present, there is no approved medical treatment for patients with clinically non-functioning pituitary adenoma. A number of open-label studies suggest that treatment with somatostatin analogues may prevent tumour progression in selected patients. In vivo assessment of somatostatin receptor status using 68Ga-DOTATATE PET could help to select patients responsive to treatment.Trial objective: To investigate the effect of the somatosta...