Searchable abstracts of presentations at key conferences in endocrinology

ea0032p989 | Thyroid (non-cancer) | ECE2013

Influence of smoking on hyperthyroidism severity in newly diagnosed Graves' disease patients

Martin Sorina , Florea Suzana , Fica Simona

Introduction: Smoking is an independent risk factor for Graves’ disease (GD) and an independent predictor for Graves’ophtalmopathy (GO), but the influence on hyperthyroidism severity was not established.Aim: To evaluate the relationship between smoking and thyroid function at diagnosis and after administration of antithyroid drugs (ATDs) in GD patients.Materials and methods: We prospectively investigated 116 newly diagnos...

ea0049ep215 | Bone & Osteoporosis | ECE2017

Osteopetrosis vs Osteogenesis Imperfecta-is that so hard to distinquish? Case report

Oprea Theodor-Eugen , Bonea Mirela , Florea Suzana , Barbu Carmen

Osteopetrosis and O.I. are both bone metabolic disorders with opposite features in terms of the metabolic turnover: while osteopetrozis has a low turnover and increased BMD due to the failure of osteoclasts to resorb bone, O.I. is well known as a high turnover disease with low BMD caused bt mutations in the COL1A1 and col COL1A2 genes that encode type 1 procollagen; yet, both condition, in spite of different mechanism, end up with increased ftracure prevalence. We report the c...

ea0041ep118 | Bone & Osteoporosis | ECE2016

Incident fragility fractures under antiresorbtive therapy in a 76 year old lady: never too late to discover new causes

Ioana Arhire Amalia , Tudose Cornelia , Florea Suzana , Gabriela Barbu Carmen

Introduction: We report a case of severe osteoporosis with incident fragility fractures during antiresorbtive therapy in the presence of amiodarone induced hypothyroidism.Case report: A 76 year old female was admitted in our department for the evaluation of antiresorbtive therapy in the context of a recent rib fracture after coughing. Severe osteoporosis (lumbar T-score: −2.8DS, femoral neck T-score: −2.9DS with multiple fra...

ea0041ep1015 | Thyroid (non-cancer) | ECE2016

Cardiovascular risk assessment using serum hs-CRP and Framingham risk score in newly diagnosed Graves’ disease patients

Martin Sorina , Betivoiu Minodora , Florea Suzana , Fica Simona

Introduction: In hyperthyroid patients mortality is increased by 20%, the major causes of death being cardiovascular disorders. Recent data suggest that subclinical or treated thyroid disease is associated with increased long-term vascular risk despite restoration of euthyroidism.Methods: We measured high-sensitivity C reactive protein (hs-CRP) in 116 newly diagnosed Graves’ disease (GD) patients, without prior antithyroid treatment. Levels of hs-CR...

ea0037ep197 | Reproduction, endocrine disruptors and signalling | ECE2015

The connection between serum prolactin, TSH, and insulin resistance in polycystic ovary syndrome patients

Albu Alice , Radian Serban , Florea Suzana , Fica Simona

Introduction: Both TSH and prolactin serum levels within normal range were previously reported to be associated with metabolic parameters.Aim: To analyse the connections between serum levels of prolactin, TSH, and insulin resistance in polycystic ovary syndrome patients.Material and methods: 322 PCOS patients (mean age 24.3±5.16 years and mean BMI 28±7.57 kg/m2) with normal serum prolactin and without thyroid d...

ea0037ep431 | Diabetes (complications & therapy) | ECE2015

Microangiopathic complications in latent autoimmune diabetes in adults: relationship with thyroid autoimmunity

Reghina Aura , Sava Elisabeta , Florea Suzana , Fica Simona

Background: Patients with latent autoimmune diabetes in adults (LADA) are a clinically, immunologically, genetically heterogeneous group and the presence of thyroid autoimmunity (TA) appears to contribute to his heterogeneity.The aim was to evaluate the impact of TA on microangiopathic complications in LADA patients.Materials and method: LADA has been defined by the onset of diabetes at ages above 30 years, the lack of need for ins...

ea0037ep652 | Pituitary: basic and neuroendocrinology | ECE2015

IGF1 deficiency in newly diagnosed Graves' disease patients

Martin Sorina , Betivoiu Minodora , Florea Suzana , Fica Simona

Introduction: Thyroid hormones influence GH/IGF1 axis, but previous studies reported discrepant results regarding serum IGF1 levels in hyperthyroidism. We have therefore investigated, at diagnosis, the relationship between serum IGF1 levels/IGF1 z scores and clinical and biological characteristics of Graves’ disease (GD) patients. We also compared IGF1 levels/IGF1 z scores, at diagnosis, between GD and autonomous hyperthyroidism patients.<p class="ab...

ea0035p3 | Adrenal cortex | ECE2014

Cardiovascular risk in Cushing's syndrome vs obesity

Martin Sorina , Ionita Andreea , Sirbu Anca , Florea Suzana , Fica Simona

Introduction: Cushing’s syndrome (CS) is associated with central obesity, hypertension, insulin resistance, dyslipidemia, prothrombotic state, manifestations which form a metabolic syndrome. Accelerated vascular senescence, due to metabolic and vascular changes, increases, in CS, the cardiovascular risk and the mortality rates compared to age- and gender-matched population. On the other hand, obesity itself is associated with numerous comorbidities, including hypertension...

ea0049ep143 | Clinical case reports - Thyroid/Others | ECE2017

MEN 1 Syndrome- a case with recurrence of neuroendocrine tumor and hyperparathyroidism after 9 years of follow up

Leca Bianca Maria , Gherasim Iustina , Sava Elisabeta , Martin Sorina , Florea Suzana , Fica Simona

Introduction: Life expectancy is decreased in MEN1 patients due to multiple tumors that may be larger, more aggressive, resistant to treatment and with a higher risk of recurrence.Case report: We report a 59-year-old male patient with family history of endocrine tumors (father- pituitary adenoma, son- primary hyperparathyroidism, daughter- microprolactinoma, primary hyperparathyroidism). He was first referred to our Clinic in 2007 after being incidendall...

ea0049ep855 | Clinical case reports - Pituitary/Adrenal | ECE2017

A case of pituitary apoplexy in a patient with Cushing’s disease due to corticotroph macroadenoma

Sava Elisabeta , Leca Bianca , Sirbu Anca , Georgescu Olivia , Cima Luminita , Florea Suzana , Fica Simona

Corticotroph macroadenomas are exceptionally found in Cushing’s disease. Pituitary apoplexy is a rare endocrine emergency condition caused by either hemorrhage or infarction of the pituitary gland. We report a case of a 56-year-old female diagnosed with type 2 diabetes in 2008. One year after, at the periodical follow up, she presented with uncontrolled diabetes (HbA1c=12.26%) and clinical manifestations suggestive for hypercortisolism, therefore insulin therapy was initi...