Endocrine Abstracts

Introduction: Smoking is an independent risk factor for Graves’ disease (GD) and an independent predictor for Graves’ophtalmopathy (GO), but the influence on hyperthyroidism severity was not established.Aim: To evaluate the relationship between smoking and thyroid function at diagnosis and after administration of antithyroid drugs (ATDs) in GD patients.Materials and methods: We prospectively investigated 116 newly diagnos...

Osteopetrosis and O.I. are both bone metabolic disorders with opposite features in terms of the metabolic turnover: while osteopetrozis has a low turnover and increased BMD due to the failure of osteoclasts to resorb bone, O.I. is well known as a high turnover disease with low BMD caused bt mutations in the COL1A1 and col COL1A2 genes that encode type 1 procollagen; yet, both condition, in spite of different mechanism, end up with increased ftracure prevalence. We report the c...

Introduction: We report a case of severe osteoporosis with incident fragility fractures during antiresorbtive therapy in the presence of amiodarone induced hypothyroidism.Case report: A 76 year old female was admitted in our department for the evaluation of antiresorbtive therapy in the context of a recent rib fracture after coughing. Severe osteoporosis (lumbar T-score: −2.8DS, femoral neck T-score: −2.9DS with multiple fra...

Introduction: In hyperthyroid patients mortality is increased by 20%, the major causes of death being cardiovascular disorders. Recent data suggest that subclinical or treated thyroid disease is associated with increased long-term vascular risk despite restoration of euthyroidism.Methods: We measured high-sensitivity C reactive protein (hs-CRP) in 116 newly diagnosed Graves’ disease (GD) patients, without prior antithyroid treatment. Levels of hs-CR...

Introduction: Both TSH and prolactin serum levels within normal range were previously reported to be associated with metabolic parameters.Aim: To analyse the connections between serum levels of prolactin, TSH, and insulin resistance in polycystic ovary syndrome patients.Material and methods: 322 PCOS patients (mean age 24.3±5.16 years and mean BMI 28±7.57 kg/m2) with normal serum prolactin and without thyroid d...

Background: Patients with latent autoimmune diabetes in adults (LADA) are a clinically, immunologically, genetically heterogeneous group and the presence of thyroid autoimmunity (TA) appears to contribute to his heterogeneity.The aim was to evaluate the impact of TA on microangiopathic complications in LADA patients.Materials and method: LADA has been defined by the onset of diabetes at ages above 30 years, the lack of need for ins...

Introduction: Thyroid hormones influence GH/IGF1 axis, but previous studies reported discrepant results regarding serum IGF1 levels in hyperthyroidism. We have therefore investigated, at diagnosis, the relationship between serum IGF1 levels/IGF1 z scores and clinical and biological characteristics of Graves’ disease (GD) patients. We also compared IGF1 levels/IGF1 z scores, at diagnosis, between GD and autonomous hyperthyroidism patients.<p class="ab...

Introduction: Cushing’s syndrome (CS) is associated with central obesity, hypertension, insulin resistance, dyslipidemia, prothrombotic state, manifestations which form a metabolic syndrome. Accelerated vascular senescence, due to metabolic and vascular changes, increases, in CS, the cardiovascular risk and the mortality rates compared to age- and gender-matched population. On the other hand, obesity itself is associated with numerous comorbidities, including hypertension...

Introduction: Life expectancy is decreased in MEN1 patients due to multiple tumors that may be larger, more aggressive, resistant to treatment and with a higher risk of recurrence.Case report: We report a 59-year-old male patient with family history of endocrine tumors (father- pituitary adenoma, son- primary hyperparathyroidism, daughter- microprolactinoma, primary hyperparathyroidism). He was first referred to our Clinic in 2007 after being incidendall...

Corticotroph macroadenomas are exceptionally found in Cushing’s disease. Pituitary apoplexy is a rare endocrine emergency condition caused by either hemorrhage or infarction of the pituitary gland. We report a case of a 56-year-old female diagnosed with type 2 diabetes in 2008. One year after, at the periodical follow up, she presented with uncontrolled diabetes (HbA1c=12.26%) and clinical manifestations suggestive for hypercortisolism, therefore insulin therapy was initi...