Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep898 | Thyroid | ECE2020

Age and sex-specific TSH upper-limit reference intervals in the general French population: There is a need to adjust our actual practices

Raverot Véronique , Maxime Bonjour , Juliette Abeillon , Pauline Perrin , Florence Roucher , Hélène Lasolle , Fabien Subtil , Borson-Chazot Francoise

Background: The increasing age of the general population represents a new challenge for endocrinologists and caregivers since it is well know that the occurrence of thyroid dysfunction increases with age. It is still controversial whether or not reference values of thyrotropin (TSH) adapted to age and sex need to be used. Herein, we aimed to determine reference intervals, in males and females, suitable for thyroid disease exploration and follow-up during adult life in a tertia...

ea0081p381 | Endocrine-Related Cancer | ECE2022

A metastatic ACC mouse model: Combined inactivation of Znrf3 & Tp53 results in consistent adrenocortical carcinoma formation

Wilmouth James , Olabe Julie , Pucheu Laly , Florence Roucher , Rodrigues Cecily Lucas , Soubeyrand-Damon Christelle , Matthias Kroiss , Landwehr Laura-Sophie , Fassnacht Martin , Lefrancois-Martinez Anne-Marie , Martinez Antoine , Val Pierre

Adrenocortical carcinoma (ACC) is an infrequent and aggressive cancer that originates from steroidogenic cells within the adrenal cortex. Half of patients present with metastatic spread at initial diagnosis, and to date, there is no curative therapy for advanced disease. Recent genomic analysis has established that the most aggressive subgroup of ACC patients have overlapping alterations in the WNT/B-catenin pathway and the p53/RB pathway. We therefore set out to develop a met...

ea0081p389 | Endocrine-Related Cancer | ECE2022

Znrf3 inactivation leads to a sexually dimorphic immune microenvironment in adrenocortical tumorigenesis

Olabe Julie , James Wilmouth , Kaitlin Basham , Cecily Lucas , Florence Roucher-Boulez , Igor Tauveron , Anne-Marie Lefrancois-Martinez , Laura-Sophie Landwehr , Matthias Kroiss , Martin Fassnacht , Gary Hammer , Antoine Martinez , Pierre Val

Adrenocortical carcinoma (ACC) is a rare and aggressive cancer that originates from steroidogenic cells within the adrenal cortex. The most common alteration in ACC patients is inactivation of the transmembrane E3 ubiquitin-ligase Zinc and Ring Finger 3 (ZNRF3), which is responsible for inhibiting the canonical WNT/Beta-catenin pathway. Using Cre/loxP strategy, we showed that inactivation of Znrf3 in the adrenal cortex resulted in an initial hyperplasia by 6-weeks, af...