Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep267 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

p63 induces the fibrosis in NASH

Fondevila Marcos F , Novoa Eva , Uxía Fernández , María J González-Rellán , Lima Natalia , Begoña Porteiro , Juan Cuñarro , Tovar Sulay , Fidalgo Miguel , Martinez-Chantar Maria Luz , Sabio Guadalupe , Marcos Miguel , Lopez Miguel , Dieguez Carlos , Rubén Nogueiras

p53 family controls several metabolic and cellular functions. The p63 member regulates lipid metabolism in hepatocytes and contributes to the development of liver steatosis. Here we show that p63 plays an important role in liver fibrosis. P63 is upregulated in patients with NASH, correlating positively with fibrosis score and collagen 1a1 expression. P63 expression is also increased in different animal models of diet-induced NASH and chemically induced liver fibrosis. Mice wit...

ea0070yi6 | Young Investigators | ECE2020

Dysregulation of splicing factor 3B SUBUNIT 1 (SF3B1) is associated with the pathological transformation of the liver: Pharmacological inhibition with pladienolide-B as novel therapeutic tool in liver disease

Jiménez Vacas1 Juan Manuel , López-Cánovas Juan L , Del Rio-Moreno Mercedes , García-Fernandez Helena , Sánchez-Frias Marina E , Amado Victor , L-López Fernando , Fondevila Marcos F , Ciria Ruben , Briceño Javier , Nogueiras Rubén , De la Mata Manuel , Castaño Justo P , Rodriguez-Perálvarez Manuel , Luque Raúl M , Gahete Manuel D

Development and progression of liver diseases, from non-alcoholic fatty liver disease (NAFLD) to steatohepatitis (NASH), and hepatocellular carcinoma (HCC), seem to be accompanied by a dysregulation of the expression of alternative splicing variants (SVs) and appearance of aberrant SVs. The splicing factor 3B subunit 1 (SF3B1) represents a crucial player for the functional assembly of the spliceosome, the core machinery that controls the splicing process, and its activity can ...