ea0056gp156 | Obesity | ECE2018
Rellan Maria Jesus Gonzalez
, Couto Begona Porteiro
, Fondevila Marcos Fernandez
, Buque Xabier
, Fernandez Uxia
, Mora Alfonso
, Beiroa Daniel
, Lopez Miguel
, Sabioc Guadalupe
, Dieguez Carlos
, Aspichueta Patricia
, Nogueiras Ruben
Introduction: p53 is a transcription factor involved in many biological functions such as stress, ageing, and metabolism. Although there is a large body of evidence showing that p53 promotes fatty acid catabolism while it inhibits anabolism through the regulation of gene expression, the possible contribution of p53 to the pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains to be elucidated. Also, the anthracycline doxorubicin is an important chemotherapeutic agent...