Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep215 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

TNF related apoptosis inducing ligand (TRAIL) reduces reactive oxygen species production by human aortic endothelial cells exposed to inflammatory stimuli

Forde Hannah , Davenport Colin , Rochfort Keith , Cummins Philip , Smith Diarmuid

Introduction: Accumulating evidence suggests that one of the most significant contributors to endothelial dysfunction is increased oxidative stress. Excessive reactive oxygen species (ROS) generation can have injurious effects within the vasculature including elevated expression of adhesion molecules, stimulation of vascular smooth muscle cell proliferation, and promotion of endothelial cell apoptosis; events which culminate in the formation and progression of atherosclerotic ...

ea0037ep384 | Diabetes (pathiophysiology & epitemiology) | ECE2015

TRAIL downregulates endothelin 1 and upregulates superoxide dismutase 1 in human aortic endothelial cells under pro-atherorgenic conditions

Forde Hannah , Davenport Colin , Smith Diarmuid , Cummins Phil

Introduction: Increased oxidative stress is associated with endothelial dysfunction in atherosclerosis and cardiovascular diseases (CVD). Evidence suggests that tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumour necrosis factor (TNF) superfamily, may also be involved in the pathogenesis of CVD. Observational studies have demonstrated that serum levels of TRAIL are inversely correlated with severity of coronary artery disease. This concurs ...

ea0086p358 | Reproductive Endocrinology | SFEBES2022

The reproductive years: the experience of women attending routine diabetes care

McDonnell Tara , O'Connor Aisling , Cussen Leanne , Madden Doyle Lauren , Forde Hannah , Smith Diarmuid , O'Reilly Michael W.

Reproductive morbidity is increased in women with diabetes, including a higher prevalence of polycystic ovary syndrome, hypothalamic amenorrhoea and premature ovarian failure. Routine discussion of reproductive and menstrual dysfunction for women with diabetes remains a peripheral feature of clinical consultations. Here we aimed to determine women’s own reproductive care experience. We surveyed women of all ages attending routine diabetes care using a detailed clinical qu...

ea0038p249 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Impact of DAFNE and subsequent CSII therapy on glycaemic control in type 1 diabetes mellitus

Yunus Saba , Forde Hannah , Browne Sonya , Twamley Helen , Fanning Eimear , Smith Diarmuid

Background: Dose adjustment for normal eating (DAFNE) structured education programme is an effective tool in improving glycaemic control in patients with type 1 diabetes while reducing the frequency of hypoglycemic episodes. DAFNE however, does not solve all glucose related problems and patients often request or are recommended continuous subcutaneous insulin infusion (CSII) therapy post DAFNE.Objective: Out of our 370 DAFNE graduates, 46 have subsequent...

ea0038p278 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Comparison of glycaemic control in patients with type-1 diabetes mellitus on CSII therapy with different basal rates

Yunus Saba Yunus , Forde Hannah , Browne Sonya , Moore Anne , Fanning Eimear , Smith Diarmuid

Background: There are very few studies comparing glycaemic control in patients with different basal rates on Continuous Subcutaneous Insulin Infusion therapy (CSII), so the ideal number of basal rates for a patient is not clear.Objective: To compare the glycaemic control between patients with different basal rates.Methods: Data were collected from hospital’s database and by contacting patients via phone....

ea0056p811 | Pituitary - Clinical | ECE2018

The diagnostic utility of late night salivary cortisol (LNSF) and cortisone (LNSE) in Cushing’s Syndrome and their relationship to metabolic markers

Garrahy Aoife , Forde Hannah , O'Kelly Patrick , McGurren Karen , Tormey William , Smith Diarmuid , Javadpour Mohsen , Agha Amar

The diagnosis of Cushing’s Syndrome (CS) requires demonstration of excess circulating cortisol. Measurement of late night salivary cortisol (LNSF) has been advocated as a simple, non-invasive and reliable outpatient diagnostic tool for patients with suspected CS but the usefulness of its metabolite cortisone (LNSE) remains unclear. LNSE levels are approximately six times higher than LNSF in saliva due to the rapid action of 11β-hydroxysteroid dehydrogenase type 2 (11...

ea0056ep116 | Pituitary and Neuroendocrinology | ECE2018

Clinical characteristics and management of 4 patients with chordomas of the skull base attending Beaumont Hospital

Maria Tudor Roxana , Forde Hannah , Agha Amar , Faul Clare , Javadpour Mohsen

Introduction: Chordomas are rare slowly growing locally aggressive neoplasms of the bone arising from embryonic remnants of notochord. These tumours typically occur in the axial skeleton and have a proclivity for the spheno-occipital region of the skull base. Parasellar/clivus chordomas account for one third of all chordomas.Methods: We conducted a retrospective chart review of 4 patients with chordomas of the clivus treated in Beaumont Hospital between ...