Searchable abstracts of presentations at key conferences in endocrinology

ea0081p650 | Environmental Endocrinology | ECE2022

Potential synergic and antagonistic effects of EDC mixtures on human prostate cells

Mileo Aldo , Riccio Lorenzo , Francesco Di Tolla Michele , D'Esposito Vittoria , Chianese Teresa , Laforgia Vincenza , Formisano Pietro , De Falco Maria

Endocrine Disrupting Chemicals (EDCs) are a heterogeneous class of compounds so called for their ability to interfere with the endocrine system. These environmental pollutants are detected in different environmental matrices; they can bioaccumulate in adipose tissue and biomagnificate in food chain due to their high hydrophobicity and low water solubility1. Two EDCs usually used in the manufacture of domestic, industrial, and agricultural products are Dibutylphtalat...

ea0014p40 | (1) | ECE2007

PED levels are increased in peripheral blood leucocytes from euglycaemic subjects at-risk of type 2 diabetes

Valentino Rossella , Lupoli Gelsy Arianna , Formisano Pietro , Esposito Iolanda , Alberobello Anna Teresa , Perfetti Anna , Cirillo Michele , Gennarelli Nicola , Gargiulo Giovanna , Lobello Roberto , Beguinot Francesco

Background: Phosphoprotein enriched in diabetes (PED) is a scaffold protein widely produced in different tissues; it is involved in multiple cellular functions, including insulin-regulated glucose transport. Previous findings showed that in individuals with type 2 diabetes (T2D) the PED gene is overexpressed in skeletal muscle (SM) and adipose tissue (AT), both target tissues for insulin activity. Our group has recently evidenced that PED protein is also expressed in periphera...