Searchable abstracts of presentations at key conferences in endocrinology

ea0026oc3.4 | Bone/Reproduction | ECE2011

Low doses of bisphenol A promote human seminoma cell proliferation in vitro by activating PKA and PKG via the non classical membrane G protein-coupled estrogen receptor (GPER)

Fenichel P , Vega A , Bouskine A , Brucker-Davis Fr , Benahmed M , Chevalier N

Fetal exposure to environmental estrogens may contribute to hypofertility and/or to testicular germ cell cancer. However, many of these endocrine disruptors have only a weak affinity for the classical ERs and other mechanisms have been suggested. Bisphenol A, a chemical poluttant, used as monomer to manufacture polycarbonate plastic, released from lining canned food or beverages or from dental sealants, was able to promote human testicular seminoma cell (JKT-1) proliferation <...

ea0022p509 | Growth factors | ECE2010

Two years of GH therapy improves body composition in adults with Prader–Willi Syndrome

Sode-Carlsen Rasmus , Farholt Stense , Rabben Kai Fr. , Bollerslev Jens , Schreiner Thomas , Christiansen Jens Sandahl , Hoybye Charlotte

Introduction: Prader–Willi syndrome (PWS) presents clinically with a multitude of findings, including abnormal body composition and partial GH deficiency. Until now three studies have reported beneficial effects upon body composition of GH treatment in adults with PWS. However, only one of these studies had the optimal randomised controlled design.Aim: The aim of this study was to confirm and substantiate the results from previous studies.<p cla...

ea0014p39 | (1) | ECE2007

1 year endurance training at the level of the ventilatory threshold in type-2 diabetics reduces by 50% healh costs: a controlled randomized trial

Jean-Frédéric Brun , Audrey Jaussent , Marie-Louise Picot , Jacques Mercier , Christian Oréfaut

This trial was undertaken in order to evaluate the effects of endurance training on health cost in type 2 diabetes. 35 diabetic patients were randomly assigned to 2 groups: After 10 drop-outs, 15 followed a training program (8 sessions followed by training at home at the level of the ventilatory threshold VT) while 10 had only routine treatment. Both groups were followed over 1 year with evaluation at 30, 120, 240 and 365 days for health costs, blood pressure, and a...

ea0014p107 | (1) | ECE2007

The role of radio-guided surgery (RGS) with the use of 99mTc-EDDA/HYNIC-octreotate in detection of unknown primary and secondary sites of neuroendocrine tumours of the gastrointestinal tract (GEP-NET) and improving the final outcome of patients

Hubalewska-Dydejczyk Alicja , Kulig Jan , Szybinski Piotr , Mikolajczak Renata , Sowa-Staszczak Anna , Fröss-Baron Katarzyna , Huszno Bohdan

Despite a wide spectrum of imaging diagnostics, GEP-NETs often stay undetectable until the time of dissemination. Removing of a primary tumour together with disseminated lymph nodes even with the presence of liver metastases is the most appropriate treatment to delay progression of the disease. SRS followed by RGS gives a possibility to detect occult GEP-NET intra-opratively. 99mTc-HYNIC/EDDA-octreotate, a somatostatin analogue with high affinity to sst2 was applied...

ea0014p421 | (1) | ECE2007

Hypophosphatemic rickets and mutations in the PHEX gene

Faivre-Defrance Frédérique , Soudan Benoit , Marcelli-Tourvieille Sophie , Wémeau Jean-Louis , Vantyghem Marie-Christine

Hypophosphatemic rickets is associated with mutations in the PHEX gene leaving phosphaturic peptides such as FGF23 uncleaved, enabling them to exert their phosphaturic potential in the kidney. Other forms are caused by mutations in the proteolytic processing site of FGF23 itself, while in tumour-induced Hp, overproduction of FGF23 causes the processing capacity to be exceeded, resulting in phosphaturic Hp. The aim of this work was to assess blood FGF23 levels in Hp patients an...

ea0014p431 | (1) | ECE2007

Endocrine function in a 48,XXYY adult

Dubois Séverine , Illouz Fréderic , Laboureau Sandrine , Draunet Catherine , Rohmer Vincent , Guichet Agnès

Within the group of gonosomal aneuploidy, the 47,XXY Klinefelter syndrome is a well-known chromosomal anomaly with a clearly delineated phenotype. Since the 48,XXYY polysomy is rather rare and associated with hypogenitalism, it has often been considered as a variant of the Klinefelter syndrome. Nevertheless, several differences have been reported, in particular the greater severity and prevalence of mental retardation and psychiatric illness in patients with a 48,XXYY syndrome...

ea0014p97 | (1) | ECE2007

Localization of an ectopic adrenocorticotropin-secreting tumour using 18F- Dopa PET/CT

Dubois Séverine , Morel Olivier , Rodien Patrice , Jeanguillaume Christian , Enon Bernard , Illouz Frédéric , Saint-André Jean-Paul , Girault Sylvie , Rohmer Vincent

Ectopic adrenocorticotropin secretion (EAS) accounts for 10–15% of cases of Cushing’s syndrome and comprises a spectrum of lesions from highly malignant tumours to a variety of less aggressive neuroendocrine tumours. Selective removal of the primary lesion is the optimal management. It is therefore mandatory to localize the source of ectopic ACTH.As no single test is accurate enough to distinguish the ectopic from the pituitary sources of ACTH,...

ea0014p98 | (1) | ECE2007

Adrenocortical carcinosarcoma: first european case report

Somda Frédéric , Leger Julie , Guy Laurent , Norha Olivier , Desbiez Françoise , Boiteux Jean-Paul , Kemeny Jean-Louis , Thieblot Philippe , Tauveron Igor

Adrenocortical sarcoma is an extremly rare tumour associated with a quite pejorative evolution.We report the case of a fifty-eight years old woman presenting a chronic asthenia and acute flank pain. She had no hypertension, no clinical sign of virilization or hypercorticism. Abdominal ultrasonography revealed an 8 centimeters mass above the right kidney. CT scan aspect evoked an adrenal carcinoma embolizing vena cava. Hormonal assays did not reveale any inappropriate secretion...

ea0014p161 | (1) | ECE2007

The modern pre- and intraoperative diagnostic algorithm of pancreatic NET with the use of 99mTc-EDDA/HYNIC-octreate scintigraphy – the impact of SRS on patients’ management

Hubalewska-Dydejczyk Alicja , Fröss-Baron Katarzyna , Mikolajczak Renata , Huszno Bogdan , Szybinski Piotr , Kulig Jan , Januszewska Aleksandra , Sowa-Staszczak Anna , Pach Dorota

Pancreatic NETs often cause difficulties in imaging diagnostics and optimal diagnostic algorithm is searched for. According to the latest reports MDCT sensitivity amounts 60-90%, MR: 80-90%, SRS: 62-100%, EUS: 70-90%.Aim: Assessment of the usefulness of 99 mTc-EDDA/HYNIC-octreotae scintigraphy in detection of primary and metastatic tumours of pancreatic NET in comparison to CT, EUS and IOUS and evaluation of the impact of scintigraphic results...

ea0073oc5.1 | Oral Communications 5: Thyroid | ECE2021

Identification of iodothyronine deiodinase 2 inhibitors among FDA-approved drug library using high throughput screening

Frädrich Caroline , Renko Kostja , Wiese Niklas , Fischbach Anja , Seyffarth Carola , Neuenschwander Martin , von Kries Jens Peter , Köhrle Josef

BackgroundDevelopment and application of novel drugs frequently fail due to adverse changes of TH-levels or thyroid histology in animal experiments. Such effects potentially arise from interference with thyroid gland function or key regulators of local thyroid hormone (TH) transport, metabolism and action. Deiodinases are key enzymes in TH in-/activation, with impact on development, cell differentiation and energy metabolism among other physiological pro...